YKT6

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.

Full Name

YKT6 V-SNARE Homolog

Function

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

Biological Process

Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:HGNC-UCL1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process retrograde transport, endosome to Golgi Source:HGNC-UCL1 Publication
Biological Process vesicle docking involved in exocytosis Source:HGNC-UCL1 Publication
Biological Process vesicle targeting Source:HGNC-UCL1 Publication

Cellular Location

Cytoplasm, cytosol
Cytoplasmic vesicle membrane
Golgi apparatus membrane
Probably cycles through vesicles between Golgi and endosomes.

PTM

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
Farnesylation is required for Golgi targeting.