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Mouse Anti-CHI3L2 Recombinant Antibody (1F8) (CBMAB-Y0073-LY)

This product is antibody recognizes YKT6. The antibody 1F8 immunoassay techniques such as: ELISA, IF, WB.
See all YKT6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F8
Antibody Isotype
IgG1
Application
ELISA, IF, WB

Basic Information

Immunogen
YKT6 (99-198 aa) partial recombinant protein with GST tag. Immunogen sequence: DEFSKQVDRI DWPVGSPATI HYPALDGHLS RYQNPREADP MTKVQAELDE TKIILHNTME SLLERGEKLD DLVSKSEVLG TQSKAFYKTA RKQNSCCAIM
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
YKT6 V-SNARE Homolog
Introduction
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
Entrez Gene ID
10652
UniProt ID
O15498
Function
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
Biological Process
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:HGNC-UCL1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process retrograde transport, endosome to Golgi Source:HGNC-UCL1 Publication
Biological Process vesicle docking involved in exocytosis Source:HGNC-UCL1 Publication
Biological Process vesicle targeting Source:HGNC-UCL1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasmic vesicle membrane
Golgi apparatus membrane
Probably cycles through vesicles between Golgi and endosomes.
PTM
Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
Farnesylation is required for Golgi targeting.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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