YWHAE

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

Full Name

YWHAE

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).

Biological Process

Biological Process cellular response to heat Source:UniProtKB1 Publication
Biological Process cerebral cortex development Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process MAPK cascade Source:UniProtKB1 Publication
Biological Process membrane repolarization during cardiac muscle cell action potential Source:BHF-UCL1 Publication
Biological Process negative regulation of calcium ion export across plasma membrane Source:SynGO-UCL1 Publication
Biological Process negative regulation of calcium ion transmembrane transporter activity Source:SynGO-UCL1 Publication
Biological Process negative regulation of peptidyl-serine dephosphorylation Source:BHF-UCL1 Publication
Biological Process neuron migration Source:Ensembl
Biological Process positive regulation of protein export from nucleus Source:UniProtKB1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein localization to nucleus Source:UniProtKB1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:SynGO-UCL1 Publication
Biological Process regulation of heart rate by cardiac conduction Source:BHF-UCL1 Publication
Biological Process regulation of heart rate by hormone Source:BHF-UCL1 Publication
Biological Process regulation of membrane repolarization Source:BHF-UCL1 Publication
Biological Process regulation of mitotic cell cycle Source:GO_Central1 Publication
Biological Process regulation of potassium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.