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YWHAQ

YWHAQ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and YWHAQ is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. YWHAQ contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Full Name
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process substantia nigra development Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
In neurons, axonally transported to the nerve terminals.
PTM
Ser-232 is probably phosphorylated by CK1.
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Anti-YWHAQ antibodies

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Mouse Anti-YWHAQ Recombinant Antibody (CBYJT-5595) (CBMAB-T5228-YJ)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-5595
Application*: E, WB, IH, IF, F
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (AT1A1) (CBMAB-1252-LY)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AT1A1
Application*: E, WB
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (5J20) (CBMAB-1251-LY)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: 5J20
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (33A) (CBMAB-1249-LY)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 33A
Application*: IH, WB
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (1A1) (CBMAB-1248-LY)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1A1
Application*: WB, E, F, IC/IF
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (16C4) (CBMAB-1247-LY)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16C4
Application*: WB, E
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (CBT2441) (V2LY-0625-LY1318)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2441
Application*: WB
Datasheet SDS

Mouse Anti-YWHAQ Recombinant Antibody (3B9) (CBMAB-0995CQ)

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Target: YWHAQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human
Clone: 3B9
Application*: F, IF, P, IP, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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