ZFPM1

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Full Name

zinc finger protein, multitype 1

Function

Biological Process

Biological Process atrial septum morphogenesis Source:BHF-UCL
Biological Process atrioventricular valve morphogenesis Source:BHF-UCL
Biological Process cardiac muscle tissue morphogenesis Source:BHF-UCL
Biological Process cell differentiation Source:GO_Central1 Publication
Biological Process definitive erythrocyte differentiation Source:Ensembl
Biological Process embryonic hemopoiesis Source:BHF-UCL
Biological Process erythrocyte differentiation Source:BHF-UCL
Biological Process granulocyte differentiation Source:Ensembl
Biological Process heart development Source:GO_Central1 Publication
Biological Process megakaryocyte development Source:Ensembl
Biological Process megakaryocyte differentiation Source:BHF-UCL
Biological Process mitral valve formation Source:BHF-UCL
Biological Process negative regulation of fat cell differentiation Source:BHF-UCL
Biological Process negative regulation of interleukin-4 production Source:BHF-UCL1 Publication
Biological Process negative regulation of mast cell differentiation Source:BHF-UCL
Biological Process negative regulation of protein binding Source:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process outflow tract morphogenesis Source:BHF-UCL
Biological Process platelet formation Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process positive regulation of type II interferon production Source:BHF-UCL1 Publication
Biological Process primitive erythrocyte differentiation Source:Ensembl
Biological Process regulation of chemokine production Source:Ensembl
Biological Process regulation of definitive erythrocyte differentiation Source:BHF-UCL1 Publication
Biological Process T-helper cell lineage commitment Source:BHF-UCL1 Publication
Biological Process tricuspid valve formation Source:BHF-UCL
Biological Process ventricular septum morphogenesis Source:BHF-UCL

Cellular Location

Nucleus