ZFYVE16

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Zinc Finger FYVE-Type Containing 16

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

Biological Process endosomal transport Source:UniProtKB1 Publication
Biological Process protein targeting to lysosome Source:UniProtKB1 Publication
Biological Process regulation of endocytosis Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process vesicle organization Source:UniProtKB1 Publication

Cytoplasm
Early endosome membrane
Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).