ZHX2

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq]
Full Name
ZHX2
Function
Acts as a transcriptional repressor (PubMed:12741956).
Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956).
May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity).
In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Biological Process
Biological Process mRNA catabolic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retinal bipolar neuron differentiation Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl
Cellular Location
Nucleus
Colocalizes with EFNB1 intracellular domain in the nucleus.
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Anti-ZHX2 antibodies

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Mouse Anti-ZHX2 (phosphorylated Ser621) Recombinant Antibody (6D720) (PTM-CBMAB-R4228-CN)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D720
Application*: E, WB
Datasheet SDS

Rabbit Anti-ZHX2 (phosphorylated Ser338) Recombinant Antibody (56A6') (PTM-CBMAB-R4227-CN)

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Target: ZHX2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 56A6'
Application*: WB
Datasheet SDS

Mouse Anti-ZHX2 Monoclonal Antibody (1B2) (CBMAB-0389-LY)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B2
Application*: IP, M
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (CBCNR-142) (CBMAB-R4109-CN)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNR-142
Application*: E, P, WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (CBCNR-141) (CBMAB-R4108-CN)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNR-141
Application*: E, WB, P
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (6D719) (CBMAB-R4107-CN)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D719
Application*: WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (3E2) (CBMAB-R4106-CN)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E2
Application*: E, WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (CBWJZ-091) (CBMAB-Z0256-WJ)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJZ-091
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (5E2) (CBMAB-Z0255-WJ)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E2
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (CBWJZ-089) (CBMAB-Z0254-WJ)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-089
Application*: WB
Datasheet SDS

Mouse Anti-ZHX2 Recombinant Antibody (CBWJZ-088) (CBMAB-Z0253-WJ)

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Target: ZHX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJZ-088
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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