Rabbit Anti-ZHX2 (phosphorylated Ser338) Recombinant Antibody (56A6') (PTM-CBMAB-R4227-CN)

Name: Rabbit Anti-ZHX2 (phosphorylated Ser338) Recombinant Antibody (56A6')
SKU: PTM-CBMAB-R4227-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

56A6'

Application

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Ser338 of human c-Raf, conjugated to KLH

Specificity

Human, Monkey, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM Sodium HEPES, pH 7.5, 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol

More Infomation

Target

Full Name

ZHX2

Introduction

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	22882
Mouse	387609
Rat	314988
Monkey	708694

UniProt ID

Human	Q9Y6X8
Mouse	Q8C0C0
Rat	Q80VX4
Monkey	H9ERC0

Function

Acts as a transcriptional repressor (PubMed:12741956).
Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956).
May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity).
In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

Biological Process

Biological Process mRNA catabolic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retinal bipolar neuron differentiation Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl

Cellular Location

Nucleus
Colocalizes with EFNB1 intracellular domain in the nucleus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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