ZMYM3

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene.

ZMYM3

Plays a role in the regulation of cell morphology and cytoskeletal organization.

Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process regulation of cell morphogenesis Source:UniProtKB1 Publication

Nucleus

A chromosomal aberration involving ZMYM3 may be a cause of X-linked intellectual disability in Xq13.1. Translocation t(X;13)(q13.1;?).