ADA Matched Antibody Pair (023) (APMAB-023LY)

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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ADA polyclonal antibody, 100 ug
Detection Antibody
Anti-ADA Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
Alternative Names
Adenosine Deaminase; EC 3.5.4.4; Adenosine Aminohydrolase; ADA1;
Entrez Gene ID
UniProt ID
More Infomation

Odumade, O. A., Plotkin, A. L., Pak, J., Idoko, O. T., Pettengill, M. A., Kollmann, T. R., ... & Smolen, K. K. (2021). Plasma Adenosine Deaminase (ADA)-1 and-2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life. Frontiers in immunology, 12, 2000.

Beukes, A., Shaw, J. A., Diacon, A. H., Irusen, E. M., & Koegelenberg, C. F. (2021). The utility of pleural fluid lactate dehydrogenase to adenosine deaminase ratio in pleural tuberculosis. Respiration, 100(1), 59-63.

Kuo, C. Y., Garabedian, E., Puck, J., Cowan, M. J., Sullivan, K. E., Buckley, R. H., ... & Kohn, D. B. (2020). Adenosine deaminase (ADA)–deficient severe combined immune deficiency (SCID) in the US Immunodeficiency Network (USIDNet) Registry. Journal of clinical immunology, 40(8), 1124-1131.

Fujiwara, S., Mimura, N., Yoshimura, H., Fujimoto, D., Ito, M., Mori, R., ... & Kohara, N. (2019). Elevated adenosine deaminase levels in the cerebrospinal fluid in immune checkpoint inhibitor-induced autoimmune encephalitis. Internal Medicine, 58(19), 2871-2874.

Kohn, D. B., Hershfield, M. S., Puck, J. M., Aiuti, A., Blincoe, A., Gaspar, H. B., ... & Grunebaum, E. (2019). Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. Journal of Allergy and Clinical Immunology, 143(3), 852-863.

Flinn, A. M., & Gennery, A. R. (2018). Adenosine deaminase deficiency: a review. Orphanet journal of rare diseases, 13(1), 1-7.

Moreno, E., Canet, J., Gracia, E., Lluís, C., Mallol, J., Canela, E. I., ... & Casadó, V. (2018). Molecular evidence of adenosine deaminase linking adenosine A2A receptor and CD26 proteins. Frontiers in pharmacology, 9, 106.

Kohn, D. B., & Gaspar, H. B. (2017). How we manage adenosine deaminase-deficient severe combined immune deficiency (ADA SCID). Journal of clinical immunology, 37(4), 351-356.

Bradford, K. L., Moretti, F. A., Carbonaro-Sarracino, D. A., Gaspar, H. B., & Kohn, D. B. (2017). Adenosine deaminase (ADA)-deficient severe combined immune deficiency (SCID): molecular pathogenesis and clinical manifestations. Journal of clinical immunology, 37(7), 626-637.

Sousa, R., Serrano, P., Gomes Dias, J., Oliveira, J. C., & Oliveira, A. (2017). Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers: C-reactive protein and adenosine deaminase. The bone & joint journal, 99(3), 351-357.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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