Sign in or Register   Sign in or Register
  |  

AFF4 Matched Antibody Pair (029) (APMAB-029LY)

This antibody pair set can be used for detecting and quantifying protein level of human AFF4.
See all AFF4 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-AFF4 polyclonal antibody, 100 ug
Detection Antibody
Anti-AFF4 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Alternative Names
AF4/FMR2 Family Member 4; Major CDK9 Elongation Factor-Associated Protein; ALL1-Fused Gene From Chromosome 5q31 Protein; AF5Q31; MCEF; ALL1 Fused Gene From 5q31; AF4/FMR2 Family, Member 4; Protein AF-5q31; CHOPS;
Entrez Gene ID
27125
UniProt ID
Q9UHB7

Hu, H., Zhang, Y., Zhao, L., Zhao, W., Wang, X., Ye, E., ... & Huang, Y. (2021). AFF4 facilitates melanoma cell progression by regulating c-Jun activity. Experimental Cell Research, 399(2), 112445.

Li, J., Ge, J., Yang, Y., Liu, B., Zheng, M., & Shi, R. (2020). Long noncoding RNA ZFPM2‐AS1 is involved in lung adenocarcinoma via miR‐511‐3p/AFF4 pathway. Journal of cellular biochemistry, 121(3), 2534-2542.

Xiao, Q., Zhang, Y., Qi, X., Chen, Y., Sheng, R., Xu, R., ... & Zhou, C. (2020). AFF4 regulates osteogenic differentiation of human dental follicle cells. International journal of oral science, 12(1), 1-11.

Gao, Q., Zheng, J., Ni, Z., Sun, P., Yang, C., Cheng, M., ... & Li, Y. (2020). The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells. Stem cells international, 2020.

Walton, S. J., Wang, H., Quintero-Cadena, P., Bateman, A., & Sternberg, P. W. (2020). Caenorhabditis elegans AF4/FMR2 family homolog affl-2 regulates heat-shock-induced gene expression. Genetics, 215(4), 1039-1054.

Cheng, M., Sheng, L., Gao, Q., Xiong, Q., Zhang, H., Wu, M., ... & Li, Y. (2019). The m 6 A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. Oncogene, 38(19), 3667-3680.

Chen, Y., & Cramer, P. (2019). Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo-and heterodimerization. Journal of Biological Chemistry, 294(27), 10663-10673.

Deng, P., Wang, J., Zhang, X., Wu, X., Ji, N., Li, J., ... & Chen, Q. (2018). AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2. Carcinogenesis, 39(7), 937-947.

Zhou, C. C., Xiong, Q. C., Zhu, X. X., Du, W., Deng, P., Li, X. B., ... & Yuan, Q. (2017). AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. Bone research, 5(1), 1-10.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used AFF4 Matched Antibody Pair (029)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare