AKR1D1 Matched Antibody Pair (055) (APMAB-055LY)

Name: AKR1D1 Matched Antibody Pair (055)
SKU: APMAB-055LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-AKR1D1 polyclonal antibody, 100 ug

Detection Antibody

Anti-AKR1D1 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]

Alternative Names

Aldo-Keto Reductase Family 1 Member D1; Delta(4)-3-Ketosteroid 5-Beta-Reductase; Delta(4)-3-Oxosteroid 5-Beta-Reductase; SRD5B1; Steroid-5-Beta-Reductase, Beta Polypeptide 1 (3-Oxo-5 Beta-Steroid Delta 4-Dehydrogenase Beta 1); Aldo-Keto Reductase Family 1, Member D1 (Delta 4-3-Ketosteroid-5-Beta-Reductase);

Entrez Gene ID

6718

UniProt ID

P51857

More Infomation

References

Zhu, P., Feng, R., Lu, X., Liao, Y., Du, Z., Zhai, W., & Chen, K. (2021). Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma. Aging (Albany NY), 13(3), 4138.

Barnard, L., Nikolaou, N., Louw, C., Schiffer, L., Gibson, H., Gilligan, L. C., ... & Storbeck, K. H. (2020). The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1. The Journal of steroid biochemistry and molecular biology, 202, 105724.

Wang, H. H., Wen, F. Q., Dai, D. L., Wang, J. S., Zhao, J., Setchell, K. D., ... & Yang, Q. H. (2018). Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature. World journal of gastroenterology, 24(35), 4086.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

AKR1D1 Matched Antibody Pair (054)

Antibody Pairs

AKR1D1 Matched Antibody Pair (054)

Related Products

AKR1D1 Matched Antibody Pair (054)

Mouse Anti-AKR1D1 Recombinant Antibody (V2-611093)

Mouse Anti-AKR1D1 Recombinant Antibody (V2-611092)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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