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Mouse Anti-AKR1D1 Recombinant Antibody (V2-611092) (CBMAB-A0245-LY)

The product is antibody recognizes AKR1D1. The antibody 1A6 immunoassay techniques such as: WB, ELISA.
See all AKR1D1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611092
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
AKR1D1 (NP_005980, 227 a.a. ~ 326 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Aldo-Keto Reductase Family 1 Member D1
Introduction
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. [provided by RefSeq]
Entrez Gene ID
6718
UniProt ID
P51857
Alternative Names
3o5bred; SRD5B1
Function
Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta4-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-4-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).
Biological Process
Androgen metabolic process Source: UniProtKB
Bile acid biosynthetic process Source: UniProtKB
Bile acid catabolic process Source: UniProtKB-KW
C21-steroid hormone metabolic process Source: UniProtKB
Cholesterol catabolic process Source: UniProtKB
Digestion Source: UniProtKB
Steroid metabolic process Source: GO_Central
Cellular Location
Cytoplasm
Involvement in disease
Congenital bile acid synthesis defect 2 (CBAS2): A condition characterized by jaundice, intrahepatic cholestasis and hepatic failure. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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