AKT1 Matched Antibody Pair (059) (APMAB-059LY)

Name: AKT1 Matched Antibody Pair (059)
SKU: APMAB-059LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-AKT1 monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-AKT1 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Alternative Names

AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;

Entrez Gene ID

207

UniProt ID

P31749

More Infomation

Zhao, J., & Zeng, Z. (2020). Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study. Medicine, 99(26).

Bozgeyik, I., & Karadag, A. (2020). The role of miR-125b-5p-AKT serine/threonine kinase 1 axis in osteosarcoma. Gene Reports, 21, 100935.

Sukmanadi, M., Sudjarwo, S. A., Effendi, M. H., Srianto, P., Madyawati, R. S. P., Lamid, M., & Plumeriastuti, H. (2020). Capsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus). Pharmacognosy Journal, 12(4).

Ou, R., Mo, L., Tang, H., Leng, S., Zhu, H., Zhao, L., ... & Xu, Y. (2020). circRNA-AKT1 sequesters miR-942-5p to upregulate AKT1 and promote cervical cancer progression. Molecular Therapy-Nucleic Acids, 20, 308-322.

Sukhorukov, V. S., Baranich, T. I., Atochin, D. N., & Glinkina, V. V. (2018). The Adaptation Role of Serine/Threonine Kinase Akt1 in Anabolism of Muscular Tissue. Biology Bulletin Reviews, 8(6), 489-496.

Zhang, T., Huang, J., Yi, Y., Zhang, X., Loor, J. J., Cao, Y., ... & Luo, J. (2018). Akt serine/threonine kinase 1 regulates de novo fatty acid synthesis through the mammalian target of rapamycin/sterol regulatory element binding protein 1 axis in dairy goat mammary epithelial cells. Journal of agricultural and food chemistry, 66(5), 1197-1205.

Yao, J., Zhang, P., Li, J., & Xu, W. (2017). MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1. Oncology letters, 14(1), 1097-1104.

Cai, K., Wang, B., Dou, H., Luan, R., Bao, X., & Chu, J. (2017). IL-17A promotes the proliferation of human nasopharyngeal carcinoma cells through p300-mediated Akt1 acetylation. Oncology letters, 13(6), 4238-4244.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

AKT1 Matched Antibody Pair (058) (CAT#: APMAB-058LY)

Antibody Pairs

AKT1 Matched Antibody Pair (058) (CAT#: APMAB-058LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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