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ALOX12 Matched Antibody Pair (067) (APMAB-067LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ALOX12 polyclonal antibody, 100 ug
Detection Antibody
Anti-ALOX12 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Alternative Names
Arachidonate 12-Lipoxygenase, 12S Type; Arachidonate 12-Lipoxygenase, 12S-Type; Platelet-Type Lipoxygenase 12; Lipoxin Synthase 12-LO; 12S-Lipoxygenase; Platelet 12-LOX; 12S-LOX; LOG12;
Entrez Gene ID
239
UniProt ID
P18054
More Infomation

Sabbir, M. G., Taylor, C. G., & Zahradka, P. (2021). Antisense overlapping long non-coding RNA regulates coding arachidonate 12-lipoxygenase gene by translational interference. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1866(10), 158987.

Mitsui, T., Makino, S., Tamiya, G., Sato, H., Kawakami, Y., Takahashi, Y., ... & Hayasaka, K. (2021). ALOX12 mutation in a family with dominantly inherited bleeding diathesis. Journal of Human Genetics, 1-7.

Mamoor, S. (2020). Arachidonate 12-lipoxygenase (ALOX12) is differentially expressed in the tumors of breast cancer patients treated with trastuzumab.

Zheng, Z., Li, Y., Jin, G., Huang, T., Zou, M., & Duan, S. (2020). The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases. Biomedicine & Pharmacotherapy, 129, 110354.

Chung, E. J., Reedy, J. L., Kwon, S., Patil, S., Valle, L., White, A. O., & Citrin, D. E. (2019). 12-lipoxygenase is a critical mediator of type II pneumocyte senescence, macrophage polarization and pulmonary fibrosis after irradiation. Radiation research, 192(4), 367-379.

Huang, Z., Xia, L., Zhou, X., Wei, C., & Mo, Q. (2019). ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis. Biochemical and biophysical research communications, 514(1), 24-30.

Kizawa, K., Fujimori, T., & Kawai, T. (2017). Arachidonate 12-lipoxygenase inhibitors promote S100A3 citrullination in cultured SW480 cells and isolated hair follicles. Biological and Pharmaceutical Bulletin, 40(4), 516-523.

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For research use only. Not intended for any clinical use.

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