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Mouse Anti-4-Aminobiphenyl Recombinant Antibody (V2-7724) (CBMAB-1903CQ)

This product is a mouse monoclonal antibody that recognizes 4-Aminobiphenyl. The antibody 4C11 can be used for immunoassay techniques such as: ELISA, IF, IHC, IHC-Fr, IHC-P.
See all 4-Aminobiphenyl antibodies
Published Data
Mouse Anti-4-Aminobiphenyl Recombinant Antibody (4C11) in IF
Immunofluorescent staining for 4ABP-DNA adducts in neonatal liver. Mice were given a single oral dose of corn oil or 80 mg 4ABP/kg, and liver was isolated 24 h. 4ABP-DNA adducts were detected with 4C11 (green) and nuclei localized with EthD1 (red). (a) 4C11, corn oil; (b) EthD1 corn oil; (c) 4C11 4ABP-exposed; and (d) EthD1 4ABP-exposed. ...View More
McQueen, C. A., & Chau, B. (2003). Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. Toxicological Sciences, 73(2), 279-286.

Summary

Host Animal
Mouse
Specificity
Chemical
Clone
V2-7724
Antibody Isotype
IgG
Application
ELISA, IF, IHC, IHC-P

Basic Information

Immunogen
4-amino Biphenyl DNA
Host Species
Mouse
Specificity
Chemical
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:2,000
IHC1:50 1:100
IF(ICC)1:50 1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Ascites
Preservative
0.1% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
4-Aminobiphenyl
Introduction
4-amino Biphenyl (4-ABP) is an arylamine (aromatic amine) compound and as one of the major carcinogenic constituents of tobacco smoke other environmental sources, it poses critical health hazards to human beings. Under the action of carcinogen activating biotransformation enzymes such as cytochrome P4501A2, 4-ABP gets metabolized to generate a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Nevertheless, the accumulation of biologically active metabolites is dependent on the balance between activation and detoxification enzymes. 4-ABP has been linked to bladder and breast cancers in human beings as well as in rodent models. Our 4-amino Biphenyl DNA antibody (4C11) is a monoclonal antiserum which recognizes 4-aminobiphenyl (4-ABP)-DNA adducts and it has been characterized by competitive enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC) and Immunocytochemistry/Immunofluorescence (ICC/IF) techniques. This antibody does not recognize the DNA adducts of several other aromatic amines tested including 1-aminopyrene, 8-nitro-1-aminopyrene, and 6-nitro-1-aminopyrene.
Alternative Names
4-Aminobiphenyl; 92-67-1; 4-Phenylaniline; 4-Aminodiphenyl; 4-BIPHENYLAMINE; Biphenyl-4-ylamine
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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