Mouse Anti-SERPINF2 Recombinant Antibody (710-1E-94) (CBMAB-A0020-YC)

Name: Mouse Anti-SERPINF2 Recombinant Antibody (710-1E-94)
SKU: CBMAB-A0020-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

710-1E-94

Application

ELISA, WB

Immunogen

Human Alpha 2 Antiplasmin

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serpin Family F Member 2

Introduction

A2AP is a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clo

Entrez Gene ID

5345

UniProt ID

P08697

Alternative Names

AAP; API; PLI; A2AP; ALPHA-2-PI; alpha-2-antiplasmin; alpha-2-AP; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin F2; serpin peptidase inhibitor, clad

Function

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

Biological Process

Acute-phase response
Blood vessel morphogenesis
Collagen fibril organization
Fibrinolysis
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Negative regulation of endopeptidase activity
Negative regulation of fibrinolysis
Negative regulation of plasminogen activation
Platelet degranulation
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of cell differentiation
Positive regulation of collagen biosynthetic process
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of JNK cascade
Positive regulation of smooth muscle cell proliferation
Positive regulation of stress fiber assembly
Positive regulation of transcription by RNA polymerase II
Positive regulation of transforming growth factor beta production
Response to organic substance

Cellular Location

Secreted

Involvement in disease

An autosomal recessive disorder resulting in severe hemorrhagic diathesis.

PTM

Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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