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Mouse Anti-A2ML1 Recombinant Antibody (V2-448592) (CBMAB-C1056-CN)

This product is a Mouse antibody that recognizes A2ML1. The antibody CBCNC-114 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all A2ML1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-448592
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Immunogen
Alpha-2-Macroglobulin Like Protein 1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:5,000
IHC1:50-1:200
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml

Target

Full Name
Alpha-2-Macroglobulin Like 1
Introduction
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Entrez Gene ID
144568
UniProt ID
A8K2U0
Alternative Names
Alpha-2-Macroglobulin Like 1; C3 And PZP-Like, Alpha-2-Macroglobulin Domain Containing 9; CPAMD9; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 9; Alpha-2-Macroglobulin-Like Protein 1; P170;
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Biological Process
Regulation of endopeptidase activity
Cellular Location
Secreted
Involvement in disease
An inflammation of the middle ear resulting in earache, fever, hearing disturbance, and vertigo.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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