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Mouse Anti-ABCB5 Recombinant Antibody (V2-634032) (CBMAB-AP026LY)


See all ABCB5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-634032
Antibody Isotype
IgG
Application
IF, IHC, WB

Basic Information

Immunogen
Synthetic Peptide
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily B Member 5
Introduction
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
340273
UniProt ID
Q2M3G0
Alternative Names
ATP Binding Cassette Subfamily B Member 5; P-Glycoprotein ABCB5; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5; ATP-Binding Cassette Protein; ABCB5 P-Gp; ATP-Binding Cassette Sub-Family B Member 5;
Function
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
Biological Process
Cell differentiation
Eye development
Regulation of membrane potential
Transmembrane transport
Cellular Location
Cell membrane

Tangella, L. P., Arooj, M., Deplazes, E., Gray, E. S., & Mancera, R. L. (2021). Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter. Computational and structural biotechnology journal, 19, 691-704.

Watanabe, S., Hayashi, R., Sasamoto, Y., Tsujikawa, M., Ksander, B. R., Frank, M. H., ... & Nishida, K. (2021). Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. Iscience, 24(6), 102688.

Riedl, J., Pickett‐Leonard, M., Eide, C., Kluth, M. A., Ganss, C., Frank, N. Y., ... & Tolar, J. (2021). ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. Stem Cells.

Yin, Q., Shi, X., Lan, S., Jin, H., & Wu, D. (2021). Effect of melanoma stem cells on melanoma metastasis. Oncology Letters, 22(1), 1-9.

Broggi, G., Musumeci, G., Puzzo, L., Russo, A., Reibaldi, M., Ragusa, M., ... & Caltabiano, R. (2019). Immunohistochemical expression of ABCB5 as a potential prognostic factor in uveal melanoma. Applied Sciences, 9(7), 1316.

Vander Beken, S., de Vries, J. C., Meier‐Schiesser, B., Meyer, P., Jiang, D., Sindrilaru, A., ... & Scharffetter‐Kochanek, K. (2019). Newly defined ATP‐binding cassette subfamily B member 5 positive dermal mesenchymal stem cells promote healing of chronic iron‐overload wounds via secretion of interleukin‐1 receptor antagonist. Stem Cells, 37(8), 1057-1074.

Xiao, J., Egger, M. E., McMasters, K. M., & Hao, H. (2018). Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines. BMC cancer, 18(1), 1-10.

Liu, L., Nielsen, F. M., Emmersen, J., Bath, C., Østergaard Hjortdal, J., Riis, S., ... & Zachar, V. (2018). Pigmentation is associated with stemness hierarchy of progenitor cells within cultured limbal epithelial cells. Stem Cells, 36(9), 1411-1420.

Wang, S., Tang, L., Lin, J., Shen, Z., Yao, Y., Wang, W., ... & Liu, Y. (2017). ABCB5 promotes melanoma metastasis through enhancing NF-κB p65 protein stability. Biochemical and biophysical research communications, 492(1), 18-26.

Yao, J., Yao, X., Tian, T., Fu, X., Wang, W., Li, S., ... & Huo, X. (2017). ABCB5–ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells. Oncology research, 25(3), 305.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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