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Rat Anti-ABCC10 Recombinant Antibody (V2-178998) (CBMAB-A0233-YC)

Provided herein is a Rat monoclonal antibody against Human ATP Binding Cassette Subfamily C Member 10. The antibody can be used for immunoassay techniques, such as FC, IHC, WB, ICC.
See all ABCC10 antibodies
Published Data
Rat Anti-ABCC10 Recombinant Antibody (M7I-3) (CBMAB-A0233-YC) in WB
A549 cells were treated with NaB (2 mM) for 24 h, and the protein expression levels of the 7 was detected via western blotting. ...View More
Shi, B., Xu, F. F., Xiang, C. P., Jia, R., Yan, C. H., Ma, S. Q., ... & Fan, P. (2020). Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells. Oncology letters, 20(5), 1-1.

Summary

Host Animal
Rat
Specificity
Human
Clone
V2-178998
Antibody Isotype
IgG
Application
FC, IHC, WB, ICC

Basic Information

Immunogen
Recombinant fragment within Human ABCC10 aa 150-300
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:20-1:50
IHC1:20
IF(ICC)1:20-1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
0.7% BSA
Preservative
0.09% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily C Member 10
Introduction
ABCC10 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GC
Entrez Gene ID
89845
UniProt ID
Q5T3U5
Alternative Names
ATP Binding Cassette Subfamily C Member 10; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10; ATP-Binding Cassette Sub-Family C Member 10; SIMRP7; MRP7; Multidrug Resistance-Associated Protein 7; EST182763;
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
Biological Process
Leukotriene metabolic process
Leukotriene transport
Transmembrane transport
Cellular Location
Cell membrane; Basolateral cell membrane

Wang, J. Q., Wang, B., Ma, L. Y., Shi, Z., Liu, H. M., Liu, Z., & Chen, Z. S. (2021). Enhancement of anticancer drug sensitivity in multidrug resistance cells overexpressing ATP-binding cassette (ABC) transporter ABCC10 by CP55, a synthetic derivative of 5-cyano-6-phenylpyrimidin. Experimental Cell Research, 112728.

Yang, Y., Ji, N., Cai, C. Y., Wang, J. Q., Lei, Z. N., Teng, Q. X., ... & Chen, Z. S. (2020). Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor. Cancer Communications, 40(7), 285-300.

Mao, X., He, Z., Zhou, F., Huang, Y., & Zhu, G. (2019). Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer. Medicine, 98(50).

Mesci, S., Marakli, S., Yazgan, B., & YILDIRIM, T. (2019). The effect of ATP-binding cassette (ABC) transporters in human cancers. International Journal of Science Letters, 1(1), 14-19.

Umérez Igartua, M. (2018). Mir-pharmacogenetics in childhood acute lymphoblastic leukemia treatment.

Zhao, H., Huang, Y., Shi, J., Dai, Y., Wu, L., & Zhou, H. (2018). ABCC10 plays a significant role in the transport of gefitinib and contributes to acquired resistance to gefitinib in NSCLC. Frontiers in pharmacology, 9, 1312.

Zhang, H., Patel, A., Wang, Y. J., Zhang, Y. K., Kathawala, R. J., Qiu, L. H., ... & Chen, Z. S. (2017). The BTK inhibitor ibrutinib (PCI-32765) overcomes paclitaxel resistance in ABCB1-and ABCC10-overexpressing cells and tumors. Molecular cancer therapeutics, 16(6), 1021-1030.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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