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Mouse Anti-ABCG1 Recombinant Antibody (V2-179077) (CBMAB-A0313-YC)

Provided herein is a Mouse monoclonal antibody against Human ATP Binding Cassette Subfamily G Member 1. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ABCG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179077
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
ATP Binding Cassette Transporter G1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:5,000
IHC1:50-1:200
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Buffer
PBS, pH7.4, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily G Member 1
Introduction
ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Entrez Gene ID
9619
UniProt ID
P45844
Alternative Names
ATP Binding Cassette Subfamily G Member 1; ATP-Binding Cassette Transporter 8; ATP-Binding Cassette, Sub-Family G (WHITE), Member 1; ABC8; White Protein Homolog (ATP-Binding Cassette Transporter 8); ATP-Binding Cassette Transporter Member 1 Of Subfamily G
Function
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Biological Process
Amyloid precursor protein catabolic process
Cholesterol efflux
Cholesterol homeostasis
Cholesterol metabolic process
Glycoprotein transport
High-density lipoprotein particle remodeling
Intracellular cholesterol transport
Intracellular receptor signaling pathway
Lipid transport
Low-density lipoprotein particle remodeling
Negative regulation of cholesterol storage
Negative regulation of macrophage derived foam cell differentiation
Phospholipid efflux
Phospholipid homeostasis
Positive regulation of amyloid-beta formation
Positive regulation of cholesterol biosynthetic process
Positive regulation of protein secretion
Regulation of cholesterol esterification
Response to lipid
Response to organic substance
Reverse cholesterol transport
Cellular Location
Golgi apparatus membrane; Cell membrane; Endoplasmic reticulum membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Topology
Cytoplasmic: 1-426 aa
Helical: 427-445 aa
Extracellular: 446-456 aa
Helical: 457-477 aa
Cytoplasmic: 478-506 aa
Helical: 507-525 aa
Extracellular: 526-533 aa
Helical: 534-555 aa
Cytoplasmic: 556-567 aa
Helical: 568-586 aa
Extracellular: 587-649 aa
Helical: 650-669 aa
Cytoplasmic: 670-678 aa
PTM
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.

Song, X., Yan, G., Wang, H., & Lou, D. (2021). Septin 4 activates PPARγ/LXRα signaling by upregulating ABCA1 and ABCG1 expression to inhibit the formation of THP‑1 macrophage‑derived foam cells. Experimental and therapeutic medicine, 22(1), 1-7.

Meng, F., Xiao, Y., Xie, L., Liu, Q., & Qian, K. (2021). Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma. Channels, 15(1), 375-385.

Yao, X., & Levine, S. J. (2021). Scavenger Hunt: SR-B1, Adrenal Insufficiency, IL-17A, and Neutrophilic Airway Inflammation in Asthma.

Dong, M., Zhang, Y., Xu, C., Wang, C., Liu, M., Zhang, Z., ... & Zhou, J. (2020). Interferon‐γ decreases ATP‐binding cassette subfamily G member 1‐mediated cholesterol efflux through small ubiquitin‐like modifier/ubiquitin‐dependent liver X receptor‐α degradation in macrophages. Biotechnology and Applied Biochemistry.

Barilla, S., Liang, N., Mileti, E., Ballaire, R., Lhomme, M., Ponnaiah, M., ... & Treuter, E. (2020). Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1. Molecular metabolism, 42, 101066.

Liu, L., Zhao, L., Chen, P., Cai, H., Hou, Z., Jin, X., ... & Qin, Y. (2020). ATP binding cassette transporters ABCG1 and ABCG16 affect reproductive development via auxin signalling in Arabidopsis. The Plant Journal, 102(6), 1172-1186.

Li, H. N., Zhao, X., Zha, Y. J., Du, F., Liu, J., & Sun, L. (2019). miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. International journal of molecular medicine, 44(6), 2003-2014.

Hou, L., Tang, S., Wu, B. J., Ong, K. L., Westerterp, M., Barter, P. J., ... & Rye, K. A. (2019). Apolipoprotein A‐l improves pancreatic β‐cell function independent of the ATP‐binding cassette transporters ABCA1 and ABCG1. The FASEB Journal, 33(7), 8479-8489.

Pandzic, E., Gelissen, I. C., Whan, R., Barter, P. J., Sviridov, D., Gaus, K., ... & Cochran, B. J. (2017). The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments. Scientific reports, 7(1), 1-10.

Wang, L., Fumoto, T., Masumoto, S., Shoji, T., Miura, T., Naraoka, M., ... & Ohkuma, H. (2017). Regression of atherosclerosis with apple procyanidins by activating the ATP-binding cassette subfamily A member 1 in a rabbit model. Atherosclerosis, 258, 56-64.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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