Rabbit Anti-ABLIM1 Recombinant Antibody (V2-12493) (CBMAB-0983-CN)

This product is a rabbit antibody that recognizes ABLIM1 of human. The antibody EPR9508 can be used for immunoassay techniques such as: WB.
See all ABLIM1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

V2-12493

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Synthetic peptide within Human ABLIM1 aa 1-100.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Buffer

9% PBS, 40% Glycerol, 0.05% BSA

Preservative

0.1% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

actin binding LIM protein 1

Introduction

This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. The protein may act as scaffold protein (By similarity). The protein may play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Entrez Gene ID

Human	3983
Mouse	226251
Rat	307989

UniProt ID

Human	O14639
Mouse	Q8K4G5
Rat	Q3KR72

Alternative Names

ABLIM; LIMAB1; LIMATIN; abLIM-1

Function

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Biological Process

Animal organ morphogenesis
Cilium assembly
Cytoskeleton organization
Lamellipodium assembly
Visual perception

Cellular Location

Cytoskeleton; Cytoplasm. Associated with the cytoskeleton.

References

Choi, K., Lee, J., & Kang, H. J. (2021). Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice. The FASEB Journal, 35(2), e21297.

Chen, X., Huang, Y., Shi, D., Nie, C., Luo, Y., Guo, L., ... & Xie, C. (2020). LncRNA ZNF667-AS1 Promotes ABLIM1 Expression by Adsorbing microRNA-1290 to Suppress Nasopharyngeal Carcinoma Cell Progression. OncoTargets and therapy, 13, 4397.

Dong, X., Feng, M., Yang, H., Liu, H., Guo, H., Gao, X., ... & Kong, R. (2020). Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. International journal of biological sciences, 16(15), 2835.

Narahara, H., Sakai, E., Yamaguchi, Y., Narahara, S., Iwatake, M., Okamoto, K., ... & Tsukuba, T. (2019). Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion. Journal of cellular physiology, 234(1), 486-499.

Jin, S. H., Kim, H., Gu, D. R., Park, K. H., Lee, Y. R., Choi, Y., & Lee, S. H. (2018). Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility. BMB reports, 51(7), 356.

Li, G., Huang, S., Yang, S., Wang, J., Cao, J., Czajkowsky, D. M., ... & Zhu, X. (2018). abLIM1 constructs non-erythroid cortical actin networks to prevent mechanical tension-induced blebbing. Cell discovery, 4(1), 1-14.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ABLIM1 Recombinant Antibody (V2-179126)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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