Rabbit Anti-ACAT2 Recombinant Antibody (V2-179235) (CBMAB-A0496-YC)

Name: Rabbit Anti-ACAT2 Recombinant Antibody (V2-179235)
SKU: CBMAB-A0496-YC
Rating: 5 (1 reviews)

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Published Data

Rabbit Anti-ACAT2 Recombinant Antibody (E1L8V) (CBMAB-A0496-YC) in WB

Alidation of systems analyses in predicting pHi-sensitive metabolic vulnerabilities. Efficiency of knockdown of indicated targets at the mRNA and protein levels, following reverse transfection of MCF7 cells with the indicated siRNAs. ...View More

Persi, E., Duran-Frigola, M., Damaghi, M., Roush, W. R., Aloy, P., Cleveland, J. L., ... & Ruppin, E. (2018). Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nature communications, 9(1), 2997.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

V2-179235

Application

WB, IP

Immunogen

Synthetic peptide corresponding to residues surrounding Val216 of human ACAT2 protein.

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IP	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Acetyl-CoA Acetyltransferase 2

Introduction

ACAT2 is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of

Entrez Gene ID

Human	39
Monkey	741276

UniProt ID

Human	O75908
Monkey	O77759

Alternative Names

Acetyl-CoA Acetyltransferase 2; EC 2.3.1.9; Acetyl-Coenzyme A Acetyltransferase 2 (Acetoacetyl Coenzyme A Thiolase); Acetyl-Coenzyme A Acetyltransferase 2; Acetyl-CoA Transferase-Like Protein; Cytosolic Acetoacetyl-CoA Thiolase; Acetoacetyl Coenzyme A Thi

Function

Involved in the biosynthetic pathway of cholesterol.

Biological Process

Cholesterol biosynthetic process
Fatty acid beta-oxidation
Lipid metabolic process

Cellular Location

Cytosol

Zhang, Y., Wei, W., Fan, J., Jin, C., Lu, L., & Fang, W. (2020). Aspergillus fumigatus mitochondrial acetyl coenzyme A acetyltransferase as an antifungal target. Applied and environmental microbiology, 86(7), e02986-19.

Ibrahim, A., Shafie, N. H., Mohd Esa, N., Shafie, S. R., Bahari, H., & Abdullah, M. A. (2020). Mikania micrantha Extract Inhibits HMG-CoA Reductase and ACAT2 and Ameliorates Hypercholesterolemia and Lipid Peroxidation in High Cholesterol-Fed Rats. Nutrients, 12(10), 3077.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ACAT2 Matched Antibody Pair (002) (CAT#: APMAB-002LY)

ACAT2 Matched Antibody Pair (003) (CAT#: APMAB-003LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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