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Mouse Anti-ADAMDEC1 Recombinant Antibody (V2-179812) (CBMAB-A1175-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Like Decysin 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all ADAMDEC1 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179812
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa361-471 from human ADAMDEC1 (NP_055294) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 361-471

Target

Full Name
ADAM-like, decysin 1
Introduction
ADAMDEC1 is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. ADAMDEC1 may play an important role in dendritic cell function and their interactions with
Entrez Gene ID
UniProt ID
Alternative Names
ADAM Like Decysin 1; A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-1; ADAM-Like Protein Decysin-1; Disintegrin Protease; EC 3.4.24.-; ADAM DEC1; M12.219; Decysin;
Function
May play an important role in the control of the immune response and during pregnancy.
Biological Process
Immune response
Negative regulation of cell adhesion
Cellular Location
Secreted

Liu, T., Deng, Z., Xie, H., Chen, M., Xu, S., Peng, Q., ... & Li, J. (2020). ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages. Biochemical and biophysical research communications, 521(1), 64-71.

Kumagai, T., Fan, S., & Smith, A. M. (2020). ADAMDEC1 and its role in inflammatory disease and cancer. Metalloproteinases In Medicine, 7, 15-28.

Jimenez-Pascual, A., Lathia, J. D., & Siebzehnrubl, F. A. (2020). ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & cellular oncology, 7(1), 1684787.

Hale, J. S., Jimenez-Pascual, A., Kordowski, A., Pugh, J., Rao, S., Silver, D. J., ... & Siebzehnrubl, F. A. (2019). ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells. bioRxiv, 531509.

Shi, L., Li, S., Maurer, K., Zhang, Z., Petri, M., & Sullivan, K. E. (2018). Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1. Molecular immunology, 103, 312-321.

Sugimoto, N., Nakayama, T., Kasai, Y., Asaka, D., Mitsuyoshi, R., Tsurumoto, T., ... & Haruna, S. I. (2018). The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps. Acta oto-laryngologica, 138(9), 830-836.

Yako, Y., Hayashi, T., Takeuchi, Y., Ishibashi, K., Kasai, N., Sato, N., ... & Fujita, Y. (2018). ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells. Scientific reports, 8(1), 1-11.

Lund, J., Elimar Bitsch, A. M., Grønbech Rasch, M., Enoksson, M., Troeberg, L., Nagase, H., ... & Petersen, H. H. (2018, January). Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma. In MAbs (Vol. 10, No. 1, pp. 118-128). Taylor & Francis.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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