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Mouse Anti-ADAMTS8 Recombinant Antibody (V2-610995) (CBMAB-A0138-LY)

The product is antibody recognizes ADAMTS8. The antibody 5A3 immunoassay techniques such as: WB, ELISA.
See all ADAMTS8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-610995
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ADAMTS8 (NP_008968, 781 a.a. ~ 890 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 8
Introduction
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq]
Entrez Gene ID
11095
Alternative Names
ADAM-TS8; FLJ41712; METH2
Function
Has anti-angiogenic properties.
Biological Process
Extracellular matrix organization
Negative regulation of cell population proliferation
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Zhang, K., Tian, R., Wang, G., Zhang, J., Ma, H., Hu, X., ... & Wang, G. (2020). ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer. OncoTargets and therapy, 13, 8373.

Li, L., Yuan, S., Zhao, X., & Luo, T. (2020). ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor. Biochemical and biophysical research communications, 524(3), 663-671.

Omura, J., Satoh, K., Kikuchi, N., Satoh, T., Kurosawa, R., Nogi, M., ... & Shimokawa, H. (2019). ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure: a possible novel therapeutic target. Circulation research, 125(10), 884-906.

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., ... & O'Shaughnessy, R. F. L. (2019). Differential expression of secreted factors SOSTDC 1 and ADAMTS 8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180(5), 1135-1149.

Zhao, X., Yang, C., Wu, J., & Nan, Y. (2018). ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma. OncoTargets and therapy, 11, 7569.

Guo, X., Li, J., Zhang, H., Liu, H., Liu, Z., & Wei, X. (2018). Relationship between ADAMTS8, ADAMTS18, and ADAMTS20 (a disintegrin and metalloproteinase with thrombospondin motifs) expressions and tumor molecular classification, clinical pathological parameters, and prognosis in breast invasive ductal carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 3726.

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For research use only. Not intended for any clinical use.

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