Human ADAMTS8 ELISA Kit (V2LY-0626-LY3839)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.27 ng/mL
Detection Range
0.5-200 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
96.5 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 8
Function
Has anti-angiogenic properties.
Biological Process
Extracellular matrix organization
Negative regulation of cell population proliferation
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Zhang, K., Tian, R., Wang, G., Zhang, J., Ma, H., Hu, X., ... & Wang, G. (2020). ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer. OncoTargets and therapy, 13, 8373.

Li, L., Yuan, S., Zhao, X., & Luo, T. (2020). ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor. Biochemical and biophysical research communications, 524(3), 663-671.

Omura, J., Satoh, K., Kikuchi, N., Satoh, T., Kurosawa, R., Nogi, M., ... & Shimokawa, H. (2019). ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure: a possible novel therapeutic target. Circulation research, 125(10), 884-906.

Badshah, I. I., Brown, S., Weibel, L., Rose, A., Way, B., Sebire, N., ... & O'Shaughnessy, R. F. L. (2019). Differential expression of secreted factors SOSTDC 1 and ADAMTS 8 cause profibrotic changes in linear morphoea fibroblasts. British Journal of Dermatology, 180(5), 1135-1149.

Zhao, X., Yang, C., Wu, J., & Nan, Y. (2018). ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma. OncoTargets and therapy, 11, 7569.

Guo, X., Li, J., Zhang, H., Liu, H., Liu, Z., & Wei, X. (2018). Relationship between ADAMTS8, ADAMTS18, and ADAMTS20 (a disintegrin and metalloproteinase with thrombospondin motifs) expressions and tumor molecular classification, clinical pathological parameters, and prognosis in breast invasive ductal carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 3726.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Adamts8 ELISA Kit (CAT#: V2LY-0626-LY1790)

Related Products

Mouse Anti-ADAMTS8 Recombinant Antibody (V2-610995) (CAT#: CBMAB-A0138-LY)

Mouse Adamts8 ELISA Kit (CAT#: V2LY-0626-LY1790)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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