Mouse Anti-ADCK1 Recombinant Antibody (V2-610997) (CBMAB-A0140-LY)

The product is antibody recognizes ADCK1. The antibody 1E8 immunoassay techniques such as: sELISA, ELISA.
See all ADCK1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

V2-610997

Antibody Isotype

IgG2a, κ

Application

ELISA

Basic Information

Immunogen

ADCK1 (AAH58906.1, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

AarF Domain Containing Kinase 1

Entrez Gene ID

57143

UniProt ID

Q86TW2

Alternative Names

FLJ39600

Function

Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).

Biological Process

Lipid homeostasis
Mitochondrion organization
Negative regulation of mitochondrial fusion
Positive regulation of cristae formation

Cellular Location

Secreted

References

Ji, Y., Liu, Y., Sun, C., Yu, L., Wang, Z., Du, X., ... & Huang, Y. (2021). ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. Cell Death & Disease, 12(4), 1-12.

Wisidagama, D. R., Thomas, S. M., Lam, G., & Thummel, C. S. (2019). Functional analysis of Aarf domain‐containing kinase 1 in Drosophila melanogaster. Developmental Dynamics, 248(9), 762-770.

Yoon, W., Hwang, S. H., Lee, S. H., & Chung, J. (2019). Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. PLoS genetics, 15(5), e1008184.

Su, Y. A., Bousman, C., Li, Q., Li, J. T., Lin, J. Y., & Si, T. M. (2019). Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia. Journal of Neural Transmission, 126(1), 19-25.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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