Human Recombinant ADCK1, Active protein, GST Tag (V2LY-0526-LY1943)

Name: Human Recombinant ADCK1, Active protein, GST Tag
SKU: V2LY-0526-LY1943
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant ADCK1, Active protein, GST Tag consist of Amino Acid: 18-end and predicts a molecular mass of 84 kDa.

Molecule Mass

84 kDa

Sequence

Amino Acid: 18-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

AarF Domain Containing Kinase 1

Function

Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).

Biological Process

Lipid homeostasis
Mitochondrion organization
Negative regulation of mitochondrial fusion
Positive regulation of cristae formation

Cellular Location

Secreted

Ji, Y., Liu, Y., Sun, C., Yu, L., Wang, Z., Du, X., ... & Huang, Y. (2021). ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. Cell Death & Disease, 12(4), 1-12.

Wisidagama, D. R., Thomas, S. M., Lam, G., & Thummel, C. S. (2019). Functional analysis of Aarf domain‐containing kinase 1 in Drosophila melanogaster. Developmental Dynamics, 248(9), 762-770.

Yoon, W., Hwang, S. H., Lee, S. H., & Chung, J. (2019). Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. PLoS genetics, 15(5), e1008184.

Su, Y. A., Bousman, C., Li, Q., Li, J. T., Lin, J. Y., & Si, T. M. (2019). Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia. Journal of Neural Transmission, 126(1), 19-25.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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