Mouse Anti-ADCY2 Recombinant Antibody (V2-179866) (CBMAB-A1243-YC)

Name: Mouse Anti-ADCY2 Recombinant Antibody (V2-179866)
SKU: CBMAB-A1243-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179866

Application

WB, IP, IF, ELISA

Immunogen

Specific for an epitope mapping between amino acids 777-802 within an internal region of A cyclase II of human origin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)	1:50-1:500
ELISA	1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 0.1% gelatin.

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

adenylate cyclase 2 (brain)

Introduction

ADCY2 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated b

Entrez Gene ID

108

UniProt ID

Q08462

Alternative Names

Adenylate Cyclase 2; Adenylate Cyclase 2 (Brain); Adenylate Cyclase Type II; ATP Pyrophosphate-Lyase 2; Adenylyl Cyclase 2; EC 4.6.1.1; 3,5-Cyclic AMP Synthetase;

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Biological Process

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
Cellular response to forskolin
Cellular response to glucagon stimulus
G protein-coupled receptor signaling pathway
Negative regulation of inflammatory response to antigenic stimulus
Renal water homeostasis

Cellular Location

Cell membrane; Cytoplasm

PTM

Phosphorylated by RAF1.

Abbas, S. Z., Altaf, A., Ali, S. K., Naqvi, S. T. Q., Ilyas, U., Qadir, M. I., & Muhammad, S. A. (2021). In silico Study of Adenylyl Cyclase Type 2 Inhibitors. GSJ, 9(4).

Huang, C. B., Shi, W. J., Wang, C. J., Chen, X. F., & Sun, T. P. (2020). Association of adenylate cyclase-2 gene polymorphism w

Chen, S. L., Hu, F., Wang, D. W., Qin, Z. Y., Liang, Y., & Dai, Y. J. (2020). Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia. Aging (Albany NY), 12(12), 11864.

Abolghasemi, M., Daneshmandpour, Y., Poursaei, E., Jamshidi, J., Baradaran, B., Shanehbandi, D., ... & Emamalizadeh, B. (2020). MMP9 (RS20544) and ADCY2 (RS58502974) as susceptibility factors for schizophrenia in Iranian population. Meta Gene, 26, 100810.

Zuo, X., Zhou, C., Zhu, X., Liu, D., Wang, Y., Bao, H., ... & Zhang, Y. (2020). ADCY2, ADCY5, and GRIA1 are the key genes of cAMP signaling pathway to participate in osteoporotic peripheral and spinal fracture after the manipulation of Wnt signaling.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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