ADCY2

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq]

Full Name

adenylate cyclase 2 (brain)

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Biological Process

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
Cellular response to forskolin
Cellular response to glucagon stimulus
G protein-coupled receptor signaling pathway
Negative regulation of inflammatory response to antigenic stimulus
Renal water homeostasis

Cellular Location

Cell membrane; Cytoplasm

PTM

Phosphorylated by RAF1.