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Mouse Anti-ADCY5 Recombinant Antibody (V2-179867) (CBMAB-A1244-YC)

Provided herein is a Mouse monoclonal antibody against Human Adenylate Cyclase 5. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ADCY5 antibodies
Published Data
Fig. 1 Dopamine D2L and AC5/6 in rat saccule.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179867
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 1152-1262 from human ADCY5 (NP_899200) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenylate Cyclase 5
Introduction
ADCY5 is a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G
Entrez Gene ID
111
UniProt ID
O95622
Alternative Names
Adenylate Cyclase 5; ATP Pyrophosphate-Lyase 5; Adenylate Cyclase Type V; Adenylyl Cyclase 5; EC 4.6.1.1; AC5; Adenylate Cyclase Type 5; FDFM;
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion.
Biological Process
Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating dopamine receptor signaling pathway
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting dopamine receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cAMP biosynthetic process
Cellular response to forskolin
Cellular response to glucagon stimulus
G protein-coupled adenosine receptor signaling pathway
G protein-coupled receptor signaling pathway
Locomotory behavior
Negative regulation of inflammatory response to antigenic stimulus
Neuromuscular process controlling balance
Positive regulation of cytosolic calcium ion concentration
Regulation of insulin secretion involved in cellular response to glucose stimulus
Renal water homeostasis
Cellular Location
Cell membrane; Cilium
Involvement in disease
Dyskinesia, familial, with facial myokymia (FDFM): A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages.
PTM
Phosphorylated by RAF1.

Li, J., Shen, C., Zhang, K., Niu, Z., Liu, Z., Zhang, S., ... & Lan, X. (2021). Polymorphic variants of bovine ADCY5 gene identified in GWAS analysis were significantly associated with ovarian morphological related traits. Gene, 766, 145158.

Dommel, S., Hoffmann, A., Berger, C., Kern, M., Klöting, N., Kannt, A., & Blüher, M. (2021). Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue. International journal of molecular sciences, 22(9), 4353.

Chen, D. H., Latimer, C. S., Spencer, M., Karna, P., Gonzalez‐Cuyar, L. F., Davis, M. Y., ... & Raskind, W. H. (2020). Hyperphosphorylated tau, increased adenylate cyclase 5 (ADCY5) immunoreactivity, but no neuronal loss in ADCY5‐dyskinesia. Movement disorders clinical practice, 7(1), 70-77.

Lin, R., Yuan, Z., Zhang, C., Ju, H., Sun, Y., Huang, N., ... & Jin, L. (2020). Common genetic variants in ADCY5 and gestational glycemic traits. PloS one, 15(3), e0230032.

Bohlega, S. A., Abou-Al-Shaar, H., AlDakheel, A., Alajlan, H., Bohlega, B. S., Meyer, B. F., ... & Al-Saif, A. M. (2019). Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders. Parkinsonism & related disorders, 64, 145-149.

Méneret, A., Gras, D., McGovern, E., & Roze, E. (2019). Caffeine and the dyskinesia related to mutations in the ADCY5 gene. Annals of internal medicine, 171(6), 439.

Niccolini, F., Mencacci, N. E., Yousaf, T., Rabiner, E. A., Salpietro, V., Pagano, G., ... & Politis, M. (2018). PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology. movement disorders, 33(12), 1961-1965.

Balint, B., Antelmi, E., Mencacci, N. E., Batla, A., Eriksson, S. H., Walker, M. C., ... & Bhatia, K. P. (2018). Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease. Parkinsonism & related disorders, 54, 103-106.

Westenberger, A., Max, C., Brüggemann, N., Domingo, A., Grütz, K., Pawlack, H., ... & Klein, C. (2017). Alternating hemiplegia of childhood as a new presentation of adenylate cyclase 5-mutation-associated disease: a report of two cases. The Journal of pediatrics, 181, 306-308.

Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., ... & Comparative Sequencing Program. (2017). A type 2 diabetes–associated functional regulatory variant in a pancreatic islet enhancer at the ADCY5 locus. Diabetes, 66(9), 2521-2530.

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For research use only. Not intended for any clinical use.

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