Mouse Anti-ADCY5 Recombinant Antibody (V2-179867) (CBMAB-A1244-YC)

Name: Mouse Anti-ADCY5 Recombinant Antibody (V2-179867)
SKU: CBMAB-A1244-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179867

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa 1152-1262 from human ADCY5 (NP_899200) with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.2

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adenylate Cyclase 5

Introduction

ADCY5 is a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G

Entrez Gene ID

111

UniProt ID

O95622

Alternative Names

Adenylate Cyclase 5; ATP Pyrophosphate-Lyase 5; Adenylate Cyclase Type V; Adenylyl Cyclase 5; EC 4.6.1.1; AC5; Adenylate Cyclase Type 5; FDFM;

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion.

Biological Process

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating dopamine receptor signaling pathway
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting dopamine receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cAMP biosynthetic process
Cellular response to forskolin
Cellular response to glucagon stimulus
G protein-coupled adenosine receptor signaling pathway
G protein-coupled receptor signaling pathway
Locomotory behavior
Negative regulation of inflammatory response to antigenic stimulus
Neuromuscular process controlling balance
Positive regulation of cytosolic calcium ion concentration
Regulation of insulin secretion involved in cellular response to glucose stimulus
Renal water homeostasis

Cellular Location

Cell membrane; Cilium

Involvement in disease

Dyskinesia, familial, with facial myokymia (FDFM): A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages.

PTM

Phosphorylated by RAF1.

Li, J., Shen, C., Zhang, K., Niu, Z., Liu, Z., Zhang, S., ... & Lan, X. (2021). Polymorphic variants of bovine ADCY5 gene identified in GWAS analysis were significantly associated with ovarian morphological related traits. Gene, 766, 145158.

Dommel, S., Hoffmann, A., Berger, C., Kern, M., Klöting, N., Kannt, A., & Blüher, M. (2021). Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue. International journal of molecular sciences, 22(9), 4353.

Chen, D. H., Latimer, C. S., Spencer, M., Karna, P., Gonzalez‐Cuyar, L. F., Davis, M. Y., ... & Raskind, W. H. (2020). Hyperphosphorylated tau, increased adenylate cyclase 5 (ADCY5) immunoreactivity, but no neuronal loss in ADCY5‐dyskinesia. Movement disorders clinical practice, 7(1), 70-77.

Lin, R., Yuan, Z., Zhang, C., Ju, H., Sun, Y., Huang, N., ... & Jin, L. (2020). Common genetic variants in ADCY5 and gestational glycemic traits. PloS one, 15(3), e0230032.

Bohlega, S. A., Abou-Al-Shaar, H., AlDakheel, A., Alajlan, H., Bohlega, B. S., Meyer, B. F., ... & Al-Saif, A. M. (2019). Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders. Parkinsonism & related disorders, 64, 145-149.

Méneret, A., Gras, D., McGovern, E., & Roze, E. (2019). Caffeine and the dyskinesia related to mutations in the ADCY5 gene. Annals of internal medicine, 171(6), 439.

Niccolini, F., Mencacci, N. E., Yousaf, T., Rabiner, E. A., Salpietro, V., Pagano, G., ... & Politis, M. (2018). PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology. movement disorders, 33(12), 1961-1965.

Balint, B., Antelmi, E., Mencacci, N. E., Batla, A., Eriksson, S. H., Walker, M. C., ... & Bhatia, K. P. (2018). Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease. Parkinsonism & related disorders, 54, 103-106.

Westenberger, A., Max, C., Brüggemann, N., Domingo, A., Grütz, K., Pawlack, H., ... & Klein, C. (2017). Alternating hemiplegia of childhood as a new presentation of adenylate cyclase 5-mutation-associated disease: a report of two cases. The Journal of pediatrics, 181, 306-308.

Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., ... & Comparative Sequencing Program. (2017). A type 2 diabetes–associated functional regulatory variant in a pancreatic islet enhancer at the ADCY5 locus. Diabetes, 66(9), 2521-2530.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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