Mouse Anti-ADH1B Recombinant Antibody (V2-179893) (CBMAB-A1277-YC)

Name: Mouse Anti-ADH1B Recombinant Antibody (V2-179893)
SKU: CBMAB-A1277-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179893

Application

IHC-F, IF, WB

Immunogen

Full length recombinant protein of human ADH1B (NP_000659) produced in HEK293T cell.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000
IF(ICC)	1:100
IHC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Buffer

PBS, pH7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide

Introduction

ADH1B is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, con

Entrez Gene ID

125

UniProt ID

P00325

Alternative Names

Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide; Alcohol Dehydrogenase Subunit Beta; EC 1.1.1.1; ADH2; Alcohol Dehydrogenase 2 (Class I), Beta Polypeptide; Epididymis Secretory Protein Li 117;

Function

Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.

Biological Process

Ethanol oxidation
Retinoic acid metabolic process
Retinoid metabolic process
Retinol metabolic process

Cellular Location

Cytoplasm

Mamoor, S. (2021). Differential expression of alcohol dehydrogenase 1B (class I), beta polypeptide in cancers of the breast.

Mamoor, S. (2020). Alcohol dehydrogenase 1B (ADH1B) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Suo, C., Yang, Y., Yuan, Z., Zhang, T., Yang, X., Qing, T., ... & Ye, W. (2019). Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk. Journal of Thoracic Oncology, 14(4), 712-725.

Polimanti, R., & Gelernter, J. (2018). ADH1B: From alcoholism, natural selection, and cancer to the human phenome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(2), 113-125.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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