Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (V2LY-0625-LY642)

Name: Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239)
SKU: V2LY-0625-LY642
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (V2LY-0625-LY642) in ELISA

Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (V2LY-0625-LY642) in WB

Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (V2LY-0625-LY642) in FC

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT3239

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

Purified recombinant fragment of human ADIPOQ (AA: 16-154) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID

9370

UniProt ID

Q15848

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process

Cellular Location

Cell membrane. Localized to the cell membrane and intracellular organelles.

Topology

Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa

More Infomation

References

Mamoor, S. (2021). Differential expression of adiponectin, C1Q and collagen domain containing in cancers of the breast.

Wang, Q., Ren, D., Bi, Y., Yuan, R., Li, D., Wang, J., ... & Liu, B. (2020). Association and functional study between ADIPOQ and metabolic syndrome in elderly Chinese Han population. Aging (Albany NY), 12(24), 25819.

Coutinho, C. A. A. C., Marson, F. A. L., Ribeiro, J. D., & Bertuzzo, C. S. (2020). A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis. Pulmonology, 26(3), 138-144.

Chung, S. J., Nagaraju, G. P., Nagalingam, A., Muniraj, N., Kuppusamy, P., Walker, A., ... & Sharma, D. (2017). ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy, 13(8), 1386-1403.

Ye, L., Wang, G., Tang, Y., & Bai, J. (2017). A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate. International journal of clinical oncology, 22(2), 307-315.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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