ADIPOQ

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Full Name
Adiponectin, C1Q And Collagen Domain Containing
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Biological Process
Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process
Cellular Location
Cell membrane. Localized to the cell membrane and intracellular organelles.
Topology
Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa
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Anti-ADIPOQ antibodies

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Mouse Anti-ADIPOQ Recombinant Antibody (V2-634147) (CBMAB-AP166LY)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: V2-634147
Application*: Dot blot, ELISA, WB
Datasheet SDS

Rat Anti-ADIPOQ Recombinant Antibody (V2-179976) (CBMAB-A1362-YC)

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Target: ADIPOQ
Host: Rat
Antibody Isotype: IgG1
Specificity: Rat
Clone: V2-179976
Application*: WB, IC
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (V2-179973) (CBMAB-A1359-YC)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179973
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (V2-179964) (CBMAB-A1350-YC)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: V2-179964
Application*: WB, P, IC
Datasheet SDS

Rat Anti-ADIPOQ Recombinant Antibody (V2-179946) (CBMAB-A1331-YC)

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Target: ADIPOQ
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: V2-179946
Application*: WB
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (V2-179941) (CBMAB-A1326-YC)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-179941
Application*: E
Datasheet SDS

Rabbit Anti-ADIPOQ Recombinant Antibody (V2-179923) (CBMAB-A1307-YC)

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Target: ADIPOQ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: V2-179923
Application*: P, WB
Datasheet SDS

Rabbit Anti-ADIPOQ Recombinant Antibody (V2-179922) (CBMAB-A1306-YC)

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Target: ADIPOQ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: V2-179922
Application*: IC, IF, P, WB
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (31/ADIPOQ) (CBMAB-A0718-YC)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179412
Application*: WB
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (V2LY-0625-LY642)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3239
Application*: F
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (CBT2700) (V2LY-0625-LY641)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2700
Application*: F
Datasheet SDS

Mouse Anti-ADIPOQ Recombinant Antibody (V2-6089) (CBMAB-0034CQ)

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Target: ADIPOQ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Rabbit, Baboon
Clone: V2-6089
Application*: E, IC, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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