Human Recombinant ADIPOQ protein, hFc Tag (V2LY-0526-LY1951)

Name: Human Recombinant ADIPOQ protein, hFc Tag
SKU: V2LY-0526-LY1951
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant ADIPOQ protein, hFc Tag consist of Amino Acid: 1-244 and predicts a molecular mass of 51.6 kDa.

Molecule Mass

51.6 kDa

Sequence

Amino Acid: 1-244

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Adiponectin, C1Q And Collagen Domain Containing

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process

Cellular Location

Cell membrane. Localized to the cell membrane and intracellular organelles.

Topology

Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa

Mamoor, S. (2021). Differential expression of adiponectin, C1Q and collagen domain containing in cancers of the breast.

Wang, Q., Ren, D., Bi, Y., Yuan, R., Li, D., Wang, J., ... & Liu, B. (2020). Association and functional study between ADIPOQ and metabolic syndrome in elderly Chinese Han population. Aging (Albany NY), 12(24), 25819.

Coutinho, C. A. A. C., Marson, F. A. L., Ribeiro, J. D., & Bertuzzo, C. S. (2020). A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis. Pulmonology, 26(3), 138-144.

Chung, S. J., Nagaraju, G. P., Nagalingam, A., Muniraj, N., Kuppusamy, P., Walker, A., ... & Sharma, D. (2017). ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy, 13(8), 1386-1403.

Ye, L., Wang, G., Tang, Y., & Bai, J. (2017). A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate. International journal of clinical oncology, 22(2), 307-315.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ADIPOQ protein, His Tag (CAT#: V2LY-0526-LY1952)

Mouse Recombinant ADIPOQ protein, His Tag (CAT#: V2LY-0526-LY7782)

Rat ADIPOQ ELISA Kit (CAT#: V2LY-0626-LY1132)

Human ADIPOQ ELISA Kit (CAT#: V2LY-0626-LY1760)

Mouse Adipoq ELISA Kit (CAT#: V2LY-0626-LY612)

Cattle ADIPOQ ELISA Kit (CAT#: V2LY-0626-LY89)

Related Products

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Human ADIPOQ ELISA Kit (CAT#: V2LY-0626-LY1760)

Mouse Anti-ADIPOQ Recombinant Antibody (V2-179973) (CAT#: CBMAB-A1359-YC)

Cattle ADIPOQ ELISA Kit (CAT#: V2LY-0626-LY89)

Mouse Anti-ADIPOQ Recombinant Antibody (CBT2700) (CAT#: V2LY-0625-LY641)

Mouse Anti-ADIPOQ Recombinant Antibody (V2-6089) (CAT#: CBMAB-0034CQ)

Mouse Anti-ADIPOQ Recombinant Antibody (V2-634147) (CAT#: CBMAB-AP166LY)

Mouse Anti-ADIPOQ Recombinant Antibody (V2-179941) (CAT#: CBMAB-A1326-YC)

Mouse Anti-ADIPOQ Recombinant Antibody (CBT3239) (CAT#: V2LY-0625-LY642)

Rabbit Anti-ADIPOQ Recombinant Antibody (V2-179923) (CAT#: CBMAB-A1307-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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