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Mouse Anti-AEBP1 Recombinant Antibody (V2-180032) (CBMAB-A1438-YC)

Provided herein is a Mouse monoclonal antibody against Human AE Binding Protein 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all AEBP1 antibodies
Published Data
Fig. 1 Immunohistochemistry of colorectal cancer tissues and adjacent non-cancerous tissues. Representative tissue sections with different immunointensities of adipocyte enhancer-binding protein 1. Histological type: 3+, strong expression.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180032
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
AEBP1 (NP_001120, 912 a.a. ~ 1013 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
AE binding protein 1
Introduction
AEBP1 is a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound heali
Entrez Gene ID
165
UniProt ID
Q8IUX7
Alternative Names
AE Binding Protein 1; Aortic Carboxypeptidase-Like Protein; AE-Binding Protein 1; ACLP; Adipocyte Enhancer Binding Protein 1; Adipocyte Enhancer-Binding Protein 1;
Function
Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.
Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
Biological Process
Negative regulation of transcription by RNA polymerase II
Regulation of collagen fibril organization
Cellular Location
Isoform 1: Secreted
Isoform 2: Cytoplasm; Nucleus
Involvement in disease
Ehlers-Danlos syndrome, classic-like, 2 (EDSCLL2): A variant form of Ehlers-Danlos syndrome, a connective tissue disorder. EDSCLL2 patients show severe joint and skin laxity, osteoporosis affecting the hips and spine, osteoarthritis, soft redundant skin that can be acrogeria-like, delayed wound healing with abnormal atrophic scarring, and shoulder, hip, knee, and ankle dislocations. Additional variable features include gastrointestinal and genitourinary manifestations (bowel rupture, gut dysmotility, cryptorchidism, and hernias), vascular complications (mitral valve prolapse and aortic root dilation), and skeletal anomalies. EDSCLL2 inheritance is autosomal recessive.
PTM
Phosphorylated by MAPK1 in vitro.

Hou, Y., Sun, B., Liu, W., Yu, B., Shi, Q., Luo, F., ... & Feng, H. (2021). Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics, 11(2), 555.

Mamoor, S. (2020). AE binding protein 1 (AEBP1) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Cheng, L., Shao, X., Wang, Q., Jiang, X., Dai, Y., & Chen, S. (2020). Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis. Pathology-Research and Practice, 216(2), 152790.

Majdalawieh, A. F., Massri, M., & Ro, H. S. (2020). AEBP1 is a novel oncogene: mechanisms of action and signaling pathways. Journal of oncology, 2020.

Wang, K., Huang, R., Wang, Z., Tong, X., & Wu, C. (2020). Molecular Characterization of AEBP1 at Transcriptional Level in Glioma.

Sinha, S., Renganathan, A., Nagendra, P. B., Bhat, V., Mathew, B. S., & Rao, M. R. S. (2019). AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells. Scientific reports, 9(1), 1-16.

Xing, Y., Zhang, Z., Chi, F., Zhou, Y., Ren, S., Zhao, Z., ... & Piao, D. (2019). AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF‐κB pathway. Molecular carcinogenesis, 58(10), 1795-1808.

Gerhard, G. S., Hanson, A., Wilhelmsen, D., Piras, I. S., Still, C. D., Chu, X., ... & DiStefano, J. K. (2019). AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p. PloS one, 14(7), e0219764.

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., ... & Iwaki, T. (2018). Association of adipocyte enhancer‐binding protein 1 with A lzheimer's disease pathology in human hippocampi. Brain pathology, 28(1), 58-71.

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For research use only. Not intended for any clinical use.

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