Mouse Anti-AEBP1 Recombinant Antibody (V2-180033) (CBMAB-A1439-YC)

Name: Mouse Anti-AEBP1 Recombinant Antibody (V2-180033)
SKU: CBMAB-A1439-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180033

Application

IHC-F, MC

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ACLP, Glu345-Phe1158.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	0.25 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

AE binding protein 1

Introduction

AEBP1 is a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound heali

Entrez Gene ID

165

UniProt ID

Q8IUX7

Alternative Names

AE Binding Protein 1; Aortic Carboxypeptidase-Like Protein; AE-Binding Protein 1; ACLP; Adipocyte Enhancer Binding Protein 1; Adipocyte Enhancer-Binding Protein 1;

Function

Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.
Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Biological Process

Negative regulation of transcription by RNA polymerase II
Regulation of collagen fibril organization

Cellular Location

Isoform 1: Secreted
Isoform 2: Cytoplasm; Nucleus

Involvement in disease

Ehlers-Danlos syndrome, classic-like, 2 (EDSCLL2): A variant form of Ehlers-Danlos syndrome, a connective tissue disorder. EDSCLL2 patients show severe joint and skin laxity, osteoporosis affecting the hips and spine, osteoarthritis, soft redundant skin that can be acrogeria-like, delayed wound healing with abnormal atrophic scarring, and shoulder, hip, knee, and ankle dislocations. Additional variable features include gastrointestinal and genitourinary manifestations (bowel rupture, gut dysmotility, cryptorchidism, and hernias), vascular complications (mitral valve prolapse and aortic root dilation), and skeletal anomalies. EDSCLL2 inheritance is autosomal recessive.

PTM

Phosphorylated by MAPK1 in vitro.

Hou, Y., Sun, B., Liu, W., Yu, B., Shi, Q., Luo, F., ... & Feng, H. (2021). Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics, 11(2), 555.

Mamoor, S. (2020). AE binding protein 1 (AEBP1) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Cheng, L., Shao, X., Wang, Q., Jiang, X., Dai, Y., & Chen, S. (2020). Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis. Pathology-Research and Practice, 216(2), 152790.

Majdalawieh, A. F., Massri, M., & Ro, H. S. (2020). AEBP1 is a novel oncogene: mechanisms of action and signaling pathways. Journal of oncology, 2020.

Wang, K., Huang, R., Wang, Z., Tong, X., & Wu, C. (2020). Molecular Characterization of AEBP1 at Transcriptional Level in Glioma.

Sinha, S., Renganathan, A., Nagendra, P. B., Bhat, V., Mathew, B. S., & Rao, M. R. S. (2019). AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells. Scientific reports, 9(1), 1-16.

Xing, Y., Zhang, Z., Chi, F., Zhou, Y., Ren, S., Zhao, Z., ... & Piao, D. (2019). AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF‐κB pathway. Molecular carcinogenesis, 58(10), 1795-1808.

Gerhard, G. S., Hanson, A., Wilhelmsen, D., Piras, I. S., Still, C. D., Chu, X., ... & DiStefano, J. K. (2019). AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p. PloS one, 14(7), e0219764.

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., ... & Iwaki, T. (2018). Association of adipocyte enhancer‐binding protein 1 with A lzheimer's disease pathology in human hippocampi. Brain pathology, 28(1), 58-71.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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