Mouse Anti-AFAP1L2 Recombinant Antibody (CBT4683) (V2LY-0625-LY584)

Name: Mouse Anti-AFAP1L2 Recombinant Antibody (CBT4683)
SKU: V2LY-0625-LY584
Rating: 5 (1 reviews)

See all AFAP1L2 antibodies

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Tested Data

Mouse Anti-AFAP1L2 Recombinant Antibody (CBT4683) (V2LY-0625-LY584) in ELISA

Mouse Anti-AFAP1L2 Recombinant Antibody (CBT4683) (V2LY-0625-LY584) in WB

Mouse Anti-AFAP1L2 Recombinant Antibody (CBT4683) (V2LY-0625-LY584) in FC

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT4683

Antibody Isotype

IgG1

Application

WB, FC

Basic Information

Immunogen

Purified recombinant fragment of human AFAP1L2 (AA: 674-818) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Actin Filament Associated Protein 1 Like 2

Entrez Gene ID

84632

UniProt ID

Q8N4X5

Function

May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.

Biological Process

Inflammatory response
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of interleukin-8 production
Positive regulation of transcription, DNA-templated
Regulation of interleukin-6 production
Regulation of mitotic cell cycle

Cellular Location

Cytoplasm

PTM

Tyrosine phosphorylated (by SRC).

More Infomation

References

Tanga, N., Kuboyama, K., Kishimoto, A., Kiyonari, H., Shiraishi, A., Suzuki, R., ... & Noda, M. (2019). The PTN‐PTPRZ signal activates the AFAP1L2‐dependent PI3K‐AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Glia, 67(5), 967-984.

Iyama, K., Matsuse, M., Mitsutake, N., Rogounovitch, T., Saenko, V., Suzuki, K., ... & Yamashita, S. (2017). Identification of three novel fusion oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in thyroid cancers of young patients in Fukushima. Thyroid, 27(6), 811-818.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-AFAP1L2 Recombinant Antibody (V2-180052)

Mouse Anti-AFAP1L2 Recombinant Antibody (CBT2512)

Mouse Anti-AFAP1L2 Monoclonal Antibody (V2-5179)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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