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Mouse Anti-AHCTF1 Recombinant Antibody (V2-180260) (CBMAB-A1693-YC)

Provided herein is a Mouse monoclonal antibody against Human AT-Hook Containing Transcription Factor 1. The antibody can be used for immunoassay techniques, such as Dot.
See all AHCTF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180260
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to the C-terminal region of ELYS of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 1% BSA, 0.05% sodium azide
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
AT-Hook Containing Transcription Factor 1
Introduction
AHCTF1 is required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. AHCTF1 may initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC
Entrez Gene ID
25909
UniProt ID
Q8WYP5
Alternative Names
AT-Hook Containing Transcription Factor 1; Putative AT-Hook-Containing Transcription Factor 1; Embryonic Large Molecule Derived From Yolk Sac; TMBS62; ELYS; ELYS Transcription Factor Like Protein TMBS62; ELYS Transcription Factor-Like Protein TMBS62;
Function
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
Biological Process
Cell division
Mitotic nuclear envelope reassembly
Mitotic spindle organization
mRNA transport
Nuclear pore complex assembly
Protein transport
Regulation of cytokinesis
Cellular Location
Cytoplasm; Nucleus; Nucleus envelope; Nucleus matrix; Nucleoplasm; Nuclear pore complex; kinetochore. Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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