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Mouse Anti-AHRR Recombinant Antibody (V2-611052) (CBMAB-A0205-LY)

The product is antibody recognizes AHRR. The antibody 5G11 immunoassay techniques such as: WB, ELISA.
See all AHRR antibodies
Published Data
Mouse Anti-AHRR Recombinant Antibody (5G11) (CBMAB-A0205-LY) in WB
Representative bands for AHRR and β-actin proteins from experimental groups treated with 10 nM TCDD for 72 h. Each band represents a pool with samples of three cell cultures obtained by Western Blot assay. B. The graph
represents the relative expression of integrated optical density for AHRR on Sertoli cells treated with 10 nM TCDD. Optical density was normalized by βactin and was expressed as mean ± SEM. The asterisk represents a statistically significant difference (p ≤ 0.05). ...View More
Ribeiro, M. A., Estill, M. S., Fernandez, G. J., Moraes, L. N., Krawetz, S. A., & Scarano, W. R. (2018). Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD. Toxicology, 409, 112-118.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611052
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IP

Basic Information

Immunogen
Amino acids 617-715 of AHRR of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
ELISA1:100-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
aryl-hydrocarbon receptor repressor
Introduction
Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. The protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B. [provided by RefSeq]
Entrez Gene ID
57491
UniProt ID
A9YTQ3
Alternative Names
AHH; AHHR; KIAA1234; MGC167813; MGC176630; bHLHe77
Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Biological Process
Regulation of transcription by RNA polymerase II
Xenobiotic metabolic process
Cellular Location
Cytoplasm; Nucleus. Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.

Kumar, P., Yadav, M., Verma, K., Dixit, R., Singh, J., Tiwary, S. K., ... & Dixit, V. K. (2021). Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer. Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association, 27(1), 54.

Chung, Y. K., Kim, J. J., Hong, M. A., Hwang, K. R., Chae, S. J., Yoon, S. H., & Choi, Y. M. (2021). Association Between Polycystic Ovary Syndrome and the Polymorphisms of Aryl Hydrocarbon Receptor Repressor, Glutathione-S-transferase T1, and Glutathione-S-transferase M1 Genes. Gynecological Endocrinology, 37(6), 558-561.

Shahin, N. N., Abd-Elwahab, G. T., Tawfiq, A. A., & Abdelgawad, H. M. (2020). Potential role of aryl hydrocarbon receptor signaling in childhood obesity. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(8), 158714.

Mohammad‐Hasani, A., Hosseinzadeh Colagar, A., & Fallah, A. (2019). Association of the human aryl hydrocarbon receptor repressor (AhRR)‐c. 565C> G transversion with male infertility: A case‐control study from Iran. Journal of cellular biochemistry, 120(6), 8999-9005.

Vogel, C. F., Ishihara, Y., Campbell, C. E., Kado, S. Y., Nguyen-Chi, A., Sweeney, C., ... & Tuscano, J. M. (2019). A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers, 11(5), 589.

Anderson, M. R., Edwin, E. A., Diamond, J. M., Ferrante Jr, A., Sonett, J., D’Ovidio, F., ... & Lederer, D. J. (2019). Aryl-Hydrocarbon Receptor Repressor Gene in Primary Graft Dysfunction after Lung Transplantation. American journal of respiratory cell and molecular biology, 61(2), 268-271.

Yang, S. Y., Ahmed, S., Satheesh, S. V., & Matthews, J. (2018). Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)-and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells. Archives of toxicology, 92(1), 225-240.

Ishihara, Y., Tsuji, M., & Vogel, C. F. (2018). Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells. Archives of biochemistry and biophysics, 642, 75-80.

Vogel, C. F., & Haarmann-Stemmann, T. (2017). The aryl hydrocarbon receptor repressor–more than a simple feedback inhibitor of AhR signaling: clues for its role in inflammation and cancer. Current opinion in toxicology, 2, 109-119.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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