Human AHRR ELISA Kit (V2LY-0626-LY3464)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0053 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
76.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
aryl-hydrocarbon receptor repressor
Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Biological Process
Regulation of transcription by RNA polymerase II
Xenobiotic metabolic process
Cellular Location
Cytoplasm; Nucleus. Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.

Kumar, P., Yadav, M., Verma, K., Dixit, R., Singh, J., Tiwary, S. K., ... & Dixit, V. K. (2021). Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer. Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association, 27(1), 54.

Chung, Y. K., Kim, J. J., Hong, M. A., Hwang, K. R., Chae, S. J., Yoon, S. H., & Choi, Y. M. (2021). Association Between Polycystic Ovary Syndrome and the Polymorphisms of Aryl Hydrocarbon Receptor Repressor, Glutathione-S-transferase T1, and Glutathione-S-transferase M1 Genes. Gynecological Endocrinology, 37(6), 558-561.

Shahin, N. N., Abd-Elwahab, G. T., Tawfiq, A. A., & Abdelgawad, H. M. (2020). Potential role of aryl hydrocarbon receptor signaling in childhood obesity. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(8), 158714.

Mohammad‐Hasani, A., Hosseinzadeh Colagar, A., & Fallah, A. (2019). Association of the human aryl hydrocarbon receptor repressor (AhRR)‐c. 565C> G transversion with male infertility: A case‐control study from Iran. Journal of cellular biochemistry, 120(6), 8999-9005.

Vogel, C. F., Ishihara, Y., Campbell, C. E., Kado, S. Y., Nguyen-Chi, A., Sweeney, C., ... & Tuscano, J. M. (2019). A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers, 11(5), 589.

Anderson, M. R., Edwin, E. A., Diamond, J. M., Ferrante Jr, A., Sonett, J., D’Ovidio, F., ... & Lederer, D. J. (2019). Aryl-Hydrocarbon Receptor Repressor Gene in Primary Graft Dysfunction after Lung Transplantation. American journal of respiratory cell and molecular biology, 61(2), 268-271.

Yang, S. Y., Ahmed, S., Satheesh, S. V., & Matthews, J. (2018). Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)-and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells. Archives of toxicology, 92(1), 225-240.

Ishihara, Y., Tsuji, M., & Vogel, C. F. (2018). Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells. Archives of biochemistry and biophysics, 642, 75-80.

Vogel, C. F., & Haarmann-Stemmann, T. (2017). The aryl hydrocarbon receptor repressor–more than a simple feedback inhibitor of AhR signaling: clues for its role in inflammation and cancer. Current opinion in toxicology, 2, 109-119.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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