Mouse Anti-AKR7A2 Recombinant Antibody (V2-180485) (CBMAB-A2000-YC)

Name: Mouse Anti-AKR7A2 Recombinant Antibody (V2-180485)
SKU: CBMAB-A2000-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180485

Application

ELISA, IP, WB

Immunogen

AKR7A2 (AAH10852. 1, 1-330 aa) full-length recombinant protein with GST tag. Immunogen sequence: MSRPPPPRVA SVLGTMEMGR RMDAPASAAA VRAFLERGHT ELDTAFMYSD GQSETILGGL GLGLGGGDCR VKIATKANPW DGKSLKPDSV RSQLETSLKR LQCPQVDLFY LHAPDHGTPV EETLHACQRL HQEGKFVELG LSNYASWEVA EICTLCKSNG WILPTVYQGM YNATTRQVET ELFPCLRHFG LRFYAYNPLA GGLLTGKYKY EDKDGKQPVG RFFGNSWAET YRNRFWKEHH FEAIALVEKA LQAAYGASAP SVTSAALRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA TEEGPLEPAV VDAFNQAWHL VAHECPNYFR

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-330

More Infomation

Target

Full Name

Aldo-Keto Reductase Family 7 Member A2

Introduction

AKR7A2 belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, t

Entrez Gene ID

8574

UniProt ID

O43488

Alternative Names

Aldo-Keto Reductase Family 7 Member A2; Succinic Semialdehyde Reductase; Aflatoxin Aldehyde Reductase; AFB1 Aldehyde Reductase 1; Aldoketoreductase 7; SSA Reductase; AFB1-AR 1; AFAR1; AFAR;

Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Biological Process

Aflatoxin metabolic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular aldehyde metabolic process Source: ProtInc
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process

Cellular Location

Cytoplasm; Golgi apparatus

Quiñones-Lombraña, A., Intini, A., & Blanco, J. G. (2019). Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes. Toxicology letters, 307, 11-16.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

AKR7A2 Matched Antibody Pair (056) (CAT#: APMAB-056LY)

AKR7A2 Matched Antibody Pair (057) (CAT#: APMAB-057LY)

Related Products

AKR7A2 Matched Antibody Pair (057) (CAT#: APMAB-057LY)

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180486) (CAT#: CBMAB-A2001-YC)

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180487) (CAT#: CBMAB-A2002-YC)

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180484) (CAT#: CBMAB-A1999-YC)

AKR7A2 Matched Antibody Pair (056) (CAT#: APMAB-056LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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