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Rabbit Anti-ALB Recombinant Antibody (V2-180607) (CBMAB-A2143-YC)

Provided herein is a Rabbit monoclonal antibody against Human Albumin. The antibody can be used for immunoassay techniques, such as ELISA, IF.
See all ALB antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-180607
Antibody Isotype
IgG
Application
ELISA, IF, WB, IP, FC

Basic Information

Immunogen
Human Serum Albumin/HSA
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IP0.5-2 μl/mg of lysate
ELISA1:5,000-1:10,000
IF(ICC)1:20-1:100
FC1:25-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Albumin
Introduction
ALB is the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as
Entrez Gene ID
UniProt ID
Alternative Names
Albumin; Serum Albumin; PRO0883; PRO0903; PRO1341; HSA;
Function
Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc> calcium> magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).
Biological Process
Cellular protein metabolic process Source: Reactome
Cellular response to starvation Source: UniProtKB
Heme biosynthetic process Source: Reactome
Heme catabolic process Source: Reactome
High-density lipoprotein particle remodeling Source: Reactome
Maintenance of mitochondrion location Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of programmed cell death Source: UniProtKB
Platelet degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Receptor-mediated endocytosis Source: Reactome
Retina homeostasis Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Hyperthyroxinemia, familial dysalbuminemic (FDAH): A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity.
Analbuminemia (ANALBA): A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides.
PTM
Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylated by FAM20C in the extracellular medium.
Acetylated on Lys-223 by acetylsalicylic acid.

Fujioka-Kobayashi, M., Schaller, B., Mourão, C. F. D. A. B., Zhang, Y., Sculean, A., & Miron, R. J. (2021). Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets, 32(1), 74-81.

Hiraoka, R., Kuwahara, K., Wen, Y. C., Yen, T. H., Hiruta, Y., Cheng, C. M., & Citterio, D. (2020). Based Device for Naked Eye Urinary Albumin/Creatinine Ratio Evaluation. ACS sensors, 5(4), 1110-1118.

Bteich, M. (2019). An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions. Heliyon, 5(11), e02879.

Miyamoto, T., Fujitani, M., Fukuyama, H., Hatanaka, S., Koizumi, Y., & Kawabata, A. (2019). The C-reactive protein/albumin ratio is useful for predicting short-term survival in cancer and noncancer patients. Journal of palliative medicine, 22(5), 532-537.

Mendes, R. D. S., Oliveira, M. V., Padilha, G. A., Rocha, N. N., Santos, C. L., Maia, L. A., ... & Silva, P. L. (2019). Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury. Respiratory research, 20(1), 1-11.

Kudou, K., Saeki, H., Nakashima, Y., Kamori, T., Kawazoe, T., Haruta, Y., ... & Maehara, Y. (2019). C‐reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer. Journal of gastroenterology and hepatology, 34(2), 355-363.

Li, S. Q., Jiang, Y. H., Lin, J., Zhang, J., Sun, F., Gao, Q. F., ... & Ying, H. Q. (2018). Albumin‐to‐fibrinogen ratio as a promising biomarker to predict clinical outcome of non‐small cell lung cancer individuals. Cancer medicine, 7(4), 1221-1231.

Oh, T. K., Song, I. A., & Lee, J. H. (2018). Clinical usefulness of C-reactive protein to albumin ratio in predicting 30-day mortality in critically ill patients: A retrospective analysis. Scientific reports, 8(1), 1-6.

Liu, Y., Chen, S., Zheng, C., Ding, M., Zhang, L., Wang, L., ... & Zhou, J. (2017). The prognostic value of the preoperative c-reactive protein/albumin ratio in ovarian cancer. BMC cancer, 17(1), 1-8.

Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., ... & Liu, W. (2017). C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncology letters, 14(6), 7417-7424.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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