Mouse Anti-ALDH3A2 Recombinant Antibody (3F7-H9-E12) (CBMAB-1061-CN)

This product is a mouse antibody that recognizes ALDH3A2 of human. The antibody 3F7-H9-E12 can be used for immunoassay techniques such as: WB, ELISA.
See all ALDH3A2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3F7-H9-E12

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

Purified recombinant Human Aldehyde dehydrogenase 10 fragments expressed in E. coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 50% Glycerol, 0.5% BSA

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Aldehyde Dehydrogenase 3 Family Member A2

Introduction

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This protein catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. It actives on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. It's also responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.

Entrez Gene ID

Human	224
Mouse	11671
Rat	65183
Rabbit	100338784

UniProt ID

Human	P51648
Mouse	P47740
Rat	P30839
Rabbit	G1T276

Alternative Names

SLS; FALDH; ALDH10

Function

Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).

Biological Process

Cellular aldehyde metabolic process Source: UniProtKB
Central nervous system development Source: UniProtKB
Epidermis development Source: UniProtKB
Fatty acid alpha-oxidation Source: Reactome
Hexadecanal metabolic process Source: UniProtKB
Peripheral nervous system development Source: UniProtKB
Phytol metabolic process Source: UniProtKB
Protein import into peroxisome membrane Source: Reactome
Protein insertion into ER membrane Source: Reactome
Sesquiterpenoid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome

Cellular Location

Microsome membrane; Endoplasmic reticulum membrane

Involvement in disease

Sjoegren-Larsson syndrome (SLS): An autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis. Ichthyosis is usually evident at birth with varying degrees of erythema and scaling, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.

Topology

Cytoplasmic: 1-463 aa
Helical: 464-484 aa

References

Rajeshwari, M., Karthi, S., Reetu, S., Efthymiou, S., Gowda, V. K., Varalakshmi, P., ... & Ashokkumar, B. (2021). Novel ALDH3A2 mutations in structural and functional domains of FALDH causing diverse clinical phenotypes in Sjögren‐Larsson Syndrome patients. Human Mutation.

Kumar, S. U., Kumar, D. T., Mandal, P. D., Sankar, S., Haldar, R., Kamaraj, B., ... & Zayed, H. (2020). Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene. Advances in Protein Chemistry and Structural Biology, 120, 349-377.

Yusuf, R. Z., Saez, B., Sharda, A., van Gastel, N., Yu, V. W., Baryawno, N., ... & Scadden, D. T. (2020). Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood, 136(11), 1303-1316.

Yin, Z., Wu, D., Shi, J., Wei, X., Jin, N., Lu, X., & Ren, X. (2020). Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis. BMC cancer, 20(1), 1-13.

Li, S., Yang, Z., Zhang, H., Peng, M., & Ma, H. (2019). Potential role of ALDH3A2 on the lipid and glucose metabolism regulated by (‐)‐hydroxycitric acid in chicken embryos. Animal Science Journal, 90(8), 961-976.

Taghdiri, M., Kashef, A., Fardaei, M., & Miryounesi, M. (2018). Identification of a novel deletion within ALDH3A2 gene in an Iranian family with Sjögren–Larsson syndrome. Clinical case reports, 6(1), 32.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-ALDH3A2 Recombinant Antibody (3F7-H9-E12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ALDH3A2 Recombinant Antibody (G9)

Mouse Anti-ALDH3A2 Recombinant Antibody (151CT1.3.1)

Mouse Anti-ALDH3A2 Recombinant Antibody (7F2)

Rabbit Anti-ALDH3A2 Recombinant Antibody (EPR15425(B))

Mouse Anti-ALDH3A2 Recombinant Antibody (STJ98463)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: