Mouse Anti-ALDH3A2 Recombinant Antibody (7F2) (CBMAB-F1123-CQ)

This product is a mouse antibody that recognizes ALDH3A2. The antibody CBXF-2434 can be used for immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all ALDH3A2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

7F2

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

Recombinant full length Human ALDH3A2.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Aldehyde Dehydrogenase 3 Family Member A2

Introduction

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

224

UniProt ID

P51648

Alternative Names

Aldehyde Dehydrogenase 3 Family Member A2; Aldehyde Dehydrogenase Family 3 Member A2; Microsomal Aldehyde Dehydrogenase; Fatty Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 10; EC 1.2.1.3;

Function

Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).

Biological Process

Cellular aldehyde metabolic process Source: UniProtKB
Central nervous system development Source: UniProtKB
Epidermis development Source: UniProtKB
Fatty acid alpha-oxidation Source: Reactome
Hexadecanal metabolic process Source: UniProtKB
Peripheral nervous system development Source: UniProtKB
Phytol metabolic process Source: UniProtKB
Protein import into peroxisome membrane Source: Reactome
Protein insertion into ER membrane Source: Reactome
Sesquiterpenoid metabolic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome

Cellular Location

Microsome membrane; Endoplasmic reticulum membrane

Involvement in disease

Sjoegren-Larsson syndrome (SLS): An autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis. Ichthyosis is usually evident at birth with varying degrees of erythema and scaling, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects.

Topology

Cytoplasmic: 1-463 aa
Helical: 464-484 aa

References

Rajeshwari, M., Karthi, S., Reetu, S., Efthymiou, S., Gowda, V. K., Varalakshmi, P., ... & Ashokkumar, B. (2021). Novel ALDH3A2 mutations in structural and functional domains of FALDH causing diverse clinical phenotypes in Sjögren‐Larsson Syndrome patients. Human Mutation.

Kumar, S. U., Kumar, D. T., Mandal, P. D., Sankar, S., Haldar, R., Kamaraj, B., ... & Zayed, H. (2020). Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene. Advances in Protein Chemistry and Structural Biology, 120, 349-377.

Yusuf, R. Z., Saez, B., Sharda, A., van Gastel, N., Yu, V. W., Baryawno, N., ... & Scadden, D. T. (2020). Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood, 136(11), 1303-1316.

Yin, Z., Wu, D., Shi, J., Wei, X., Jin, N., Lu, X., & Ren, X. (2020). Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis. BMC cancer, 20(1), 1-13.

Li, S., Yang, Z., Zhang, H., Peng, M., & Ma, H. (2019). Potential role of ALDH3A2 on the lipid and glucose metabolism regulated by (‐)‐hydroxycitric acid in chicken embryos. Animal Science Journal, 90(8), 961-976.

Taghdiri, M., Kashef, A., Fardaei, M., & Miryounesi, M. (2018). Identification of a novel deletion within ALDH3A2 gene in an Iranian family with Sjögren–Larsson syndrome. Clinical case reports, 6(1), 32.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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