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Mouse Anti-ALPK2 Recombinant Antibody (4B5) (CBMAB-H0015-FY)

This product is mouse antibody that recognizes ALPK2. The antibody CBFYH-0013 can be used for immunoassay techniques such as: ELISA, WB.
See all ALPK2 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ALPK2 (NP_443179, 201 a.a. ~ 309 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alpha Kinase 2
Introduction
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
Entrez Gene ID
UniProt ID
Alternative Names
Alpha Kinase 2; Heart Alpha-Protein Kinase; Heart Alpha-Kinase; HAK; Alpha-Protein Kinase 2; EC 2.7.11.-
Function
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752).
Biological Process
Cardiac muscle cell development Source: UniProtKB
Epicardium morphogenesis Source: UniProtKB
Establishment of cell polarity Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Negative regulation of Wnt signaling pathway involved in heart development Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Cellular Location
Basolateral cell membrane

Mamoor, S. (2021). ALPK2 is a differentially expressed gene in brain metastatic human breast cancer.

Wang, Y., Wu, J., Luo, W., Zhang, H., Shi, G., Shen, Y., ... & Zhu, Y. (2021). ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A. Cell death & disease, 12(7), 1-10.

McIntosh, A. T., Wei, R., Ahn, J., Aouizerat, B. E., Kassaye, S. G., Augenbraun, M. H., ... & Goldman, R. (2021). A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women. PloS one, 16(3), e0247277.

Bogomolovas, J., Feng, W., Yu, M. D., Huang, S., Zhang, L., Trexler, C., ... & Chen, J. (2020). Atypical ALPK2 kinase is not essential for cardiac development and function. American Journal of Physiology-Heart and Circulatory Physiology, 318(6), H1509-H1515.

Zhu, X., Yan, S., Xiao, S., & Xue, M. (2020). Knockdown of ALPK2 inhibits the development and progression of Ovarian Cancer. Cancer Cell International, 20(1), 1-10.

Jiang, J., Han, P., Qian, J., Zhang, S., Wang, S., Cao, Q., & Shao, P. (2020). Knockdown of ALPK2 blocks development and progression of renal cell carcinoma. Experimental cell research, 392(2), 112029.

Hofsteen, P., Robitaille, A. M., Strash, N., Palpant, N., Moon, R. T., Pabon, L., & Murry, C. E. (2018). ALPK2 promotes cardiogenesis in zebrafish and human pluripotent stem cells. Iscience, 2, 88-100.

Nishi, K., Luo, H., Nakabayashi, K., Doi, K., Ishikura, S., Iwaihara, Y., ... & Tsunoda, T. (2017). An Alpha-kinase 2 gene variant disrupts filamentous actin localization in the surface cells of colorectal cancer spheroids. Anticancer research, 37(7), 3855-3862.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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