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Mouse Anti-AMIGO1 Recombinant Antibody (S86-36) (CBMAB-A2539-YC)

Provided herein is a Mouse monoclonal antibody against Human Adhesion Molecule With Ig Like Domain 1. The antibody can be used for immunoassay techniques, such as ICC, IHC, WB.
See all AMIGO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S86-36
Antibody Isotype
IgG1
Application
ICC, IHC, WB

Basic Information

Immunogen
Fusion protein amino acids 394-492 (cytoplasmic C-terminus) of mouse AMIGO-1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 554-574

Target

Full Name
Adhesion Molecule With Ig Like Domain 1
Introduction
AMIGO1 promotes growth and fasciculation of neurites from cultured hippocampal neurons. AMIGO1 may be involved in fasciculation as well as myelination of developing neural axons. AMIGO1 may have a role in regeneration as well as neural plasticity in the a
Entrez Gene ID
57463
UniProt ID
Q86WK6
Alternative Names
Adhesion Molecule With Ig Like Domain 1; Alivin-2; AMIGO-1; AMIGO; ALI2; Amphoterin-Induced Gene And Open Reading Frame; Amphoterin-Induced Gene And ORF; Amphoterin-Induced Protein 1; KIAA1163;
Function
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Biological Process
Axonal fasciculation Source: UniProtKB
Axonogenesis Source: Ensembl
Brain development Source: GO_Central
Cellular response to L-glutamate Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Myelination Source: UniProtKB
Positive regulation of axonogenesis Source: UniProtKB
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of potassium ion transmembrane transport Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl
Positive regulation of voltage-gated potassium channel activity Source: Ensembl
Cellular Location
Cell membrane; Perikaryon; Dendrite; Axon. Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells.
Topology
Extracellular: 28-372 aa
Helical: 373-393 aa
Cytoplasmic: 394-493 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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