AMIGO1

Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Full Name

Adhesion Molecule With Ig Like Domain 1

Function

Biological Process

Axonal fasciculation Source: UniProtKB
Axonogenesis Source: Ensembl
Brain development Source: GO_Central
Cellular response to L-glutamate Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Myelination Source: UniProtKB
Positive regulation of axonogenesis Source: UniProtKB
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of potassium ion transmembrane transport Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl
Positive regulation of voltage-gated potassium channel activity Source: Ensembl

Cellular Location

Cell membrane; Perikaryon; Dendrite; Axon. Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells.

Topology

Extracellular: 28-372 aa
Helical: 373-393 aa
Cytoplasmic: 394-493 aa