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Rat Anti-ANGPTL6 Recombinant Antibody (766544) (CBMAB-A2730-YC)

Provided herein is a Rat monoclonal antibody against Mouse Angiopoietin Like 6. The antibody can be used for immunoassay techniques, such as ICC, WB.
See all ANGPTL6 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
766544
Antibody Isotype
IgG2a
Application
ICC, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa25-457 from mouse ANGPTL6 expressed in E. coli (Q8ROZ6)
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5 µg/ml
IF(ICC)8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
angiopoietin-like 6
Introduction
ANGPTL6 may play a role in the wound healing process. ANGPTL6 may promote epidermal proliferation, remodeling and regeneration and promote the chemotactic activity of endothelial cells and induce neovascularization. ANGPTL6 may counteract high-fat diet-in
Entrez Gene ID
70726
UniProt ID
Q8R0Z6
Alternative Names
Angiopoietin Like 6; Angiopoietin-Related Protein 5; Angiopoietin-Related Growth Factor; Angiopoietin-Like Protein 6; Arp5; AGF; Angiopoietin-Related Protein 6; Angiopoietin-Like 6;
Function
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Cellular Location
Secreted

Qaddoumi, M. G., Alanbaei, M., Hammad, M. M., Al Khairi, I., Cherian, P., Channanath, A., ... & Abubaker, J. (2020). Investigating the role of myeloperoxidase and angiopoietin-like protein 6 in obesity and diabetes. Scientific reports, 10(1), 1-10.

Fan, K. C., Wu, H. T., Wei, J. N., Chuang, L. M., Hsu, C. Y., Yen, I., ... & Li, H. Y. (2020). Serum angiopoietin-like protein 6, risk of type 2 diabetes, and response to hyperglycemia: a prospective cohort study. The Journal of Clinical Endocrinology & Metabolism, 105(5), e1949-e1957.

Namkung, J., Sohn, J. H., Chang, J. S., Park, S. W., Kim, J. Y., Koh, S. B., ... & Park, K. S. (2019). Increased serum angiopoietin-like 6 ahead of metabolic syndrome in a prospective cohort study. Diabetes & metabolism journal, 43(4), 521-529.

Erkan, G., Muratoglu, S., Ercin, U., & Bilgihan, A. (2018). Angiopoietin-like protein 2 and angiopoietin-like protein 6 levels in patients with nonalcoholic fatty liver disease. Archives of medical science: AMS, 14(4), 781.

Kim, M. J., Namkung, J., Chang, J. S., Kim, S. J., Park, K. S., & Kong, I. D. (2018). Leptin regulates the expression of angiopoietin-like 6. Biochemical and biophysical research communications, 502(3), 397-402.

Sharma, V., Pangtey, G. S., Gupta, R., Rehan, H. S., & Gupta, L. K. (2017). Correlation of long-term glycemic control as measured by glycated hemoglobin with serum angiopoietin-like 6 protein levels in type 2 diabetes mellitus patients. Indian journal of pharmacology, 49(3), 250.

Cinkajzlova, A., Lacinova, Z., Klouckova, J., Kavalkova, P., Trachta, P., Kosak, M., ... & Haluzík, M. (2017). Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation. Endocrine research, 42(1), 22-30.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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