Mouse Anti-ANTXR2 Recombinant Antibody (CBYC-A621) (CBMAB-A2869-YC)

Name: Mouse Anti-ANTXR2 Recombinant Antibody (CBYC-A621)
SKU: CBMAB-A2869-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-A621

Application

ELISA

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2 Ser22-Arg200.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Anthrax Toxin Receptor 2

Introduction

ANTXR2 is a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis.

Entrez Gene ID

Human	118429
Mouse	71914
Rat	305633

UniProt ID

Human	P58335
Mouse	Q6DFX2
Rat	F1LT78

Alternative Names

Anthrax Toxin Receptor 2; Capillary Morphogenesis Gene 2 Protein; Capillary Morphogenesis Protein 2; CMG-2; CMG2; HFS; ISH; JHF;

Function

Necessary for cellular interactions with laminin and the extracellular matrix.

Biological Process

Toxin transport Source: GO_Central

Cellular Location

Isoform 1: Cell membrane. Expressed at the cell surface.
Isoform 2: Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
Isoform 3: Secreted

Involvement in disease

Hyaline fibromatosis syndrome (HFS): An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits.

Topology

Extracellular: 34-318 aa
Helical: 319-341 aa
Cytoplasmic: 342-489 aa

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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